FCRL1 / IFGP1 Protein (His Tag)

Fc Receptor-Like Protein 1 ( FCRL1 / IFGP1 ) Protein

FCRL1 / IFGP1 Protein Product Information

• Synonym: DKFZp667O1421, FCRH1, IFGP1, IRTA5
• Protein Construction: A DNA sequence encoding the human FCRL1 ( NP_001890.1 ) extracellular domain ( Met 1 - Asn 303 ) was fused with a polyhistidine tag at the C-terminus
• Source: Human
• Expression Host: Human Cells

FCRL1 / IFGP1 Protein QC Testing

• Purity: > 98 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Ala 17
• Molecular Mass: The secreted recombinant human FCRL1 consists of 298 amino acids and has a calculated molecular mass of 32.6 kDa. It migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS, pH 7.4 , 1 mM EDTA
• SDS-PAGE: FCRL1 protein

FCRL1 / IFGP1 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FCRL1 / IFGP1 Protein Description

Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I  membrane protein which contains three Ig-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.

References

1. Du, X. et al., 2008, Blood , 111 (1): 338-43.
2. Kazemi, T. et al., 2008,Int J Cancer. 123 (9):2113-9.
3. Baranov, K. et al., 2008, J Immunol Methods  332 (1-2):73-81.