FCN1 Protein & Antibody

Ficolin 1

FCN1 Products

FCN1 Protein, Recombinant

Molecule	Species	Description	Cat. No
FCN1/Ficolin 1	Human	FCN 1 Protein, Recombinant	10930-H08H

  10930-H08H:  Immobilized FCN1 at 10 µg/mL can bind biotinylated recombinant human Fetuin-A with a linear range of 16–2000 ng/ml. Immobilized FCN1 at 10 µg/mL can bind biotinylated recombinant mouse Fetuin-A with a linear range of 16–2000 ng/ml. Measured by its binding ability in a functional ELISA.

FCN1 Antibody

Molecule	Application	Description	Cat. No
Human FCN1/Ficolin 1	WB, ELISA	FCN1/Ficolin 1 Antibody, Rabbit PAb	10930-RP01
Human FCN1/Ficolin 1	WB, ELISA	FCN1/Ficolin 1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10930-RP02
Human FCN1/Ficolin 1	ELISA	FCN1 Antibody	10930-MM03
Human FCN1/Ficolin 1	WB	FCN1 Antibody	10930-MM06

FCN1 cDNA Clone

Molecule	Species	Description	Cat. No
FCN1/Ficolin 1	Human	Homo sapiens FCN1 cDNA Clone(NM_002003.2)	HG10930-M
FCN1/Ficolin 1	Mouse	FCNA cDNA Clone / ORF Clone	MG50920-G
FCN1/Ficolin 1	Rat	FCN1 cDNA Clone / ORF Clone	RG80255-G

FCN1 Related Areas

Immunology>>Adhesion Molecule>>Lectin>>FCN1/Ficolin 1

FCN1 Alternative Names

FCN1, ficolin 1, FCNM [Homo sapiens]

Fcn1, Fcna, ficolin A, RP23-464C2.11 [Mus musculus]

FCN1 Background

Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.

FCN1 Related Studies

1. Thiel S. (2007) Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 44(16): 3875-88.
2. Zhang XL, et al. (2008) Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 632: 105-15.
3. Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.