Anti-FCN1 Antibody

Cat: 10930-RP02
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Anti-FCN1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FCN1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human FCN1
Immunogen
Recombinant Human FCN1 Protein (Catalog#10930-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human FCN1 (rh FCN1; Catalog#10930-H08H; NP_001994.2; Met 1-Ala 326). FCN1 specific IgG was purified by human FCN1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FCN1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:2500-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FCN1 Antibody (Rabbit Polyclonal antibody) Images
Human FCN1/FCNA Immunohistochemistry(IHC) 4202
Immunochemical staining of human FCN1 in human placenta with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). Positive staining was localized to peripheral blood leukocytes.
Human FCN1/FCNA Immunohistochemistry(IHC) 4204
Immunochemical staining of human FCN1 in human liver with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). Positive staining was localized to peripheral blood leukocytes.
Anti-FCN1 Antibody Alternative Names
Anti-FCN1 Antibody;Anti-FCNA Antibody;Anti-FCNM Antibody
FCN1 Background Information

Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.

Full Name
ficolin 1
References
  • Thiel S. (2007) Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 44(16): 3875-88.
  • Zhang XL, et al. (2008) Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 632: 105-15.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FCN1 Antibody Mouse Monoclonal ELISA(Cap) 10930-MM05
    Anti-FCN1 Antibody Mouse Monoclonal IHC-P 10930-MM08
    Anti-FCN1 Antibody Rabbit Monoclonal ELISA 10930-R001
    Anti-FCN1 Antibody Mouse Monoclonal ELISA 10930-MM03
    Anti-FCN1 Antibody Rabbit Monoclonal IHC-P 10930-R017
    Anti-FCN1 Antibody Rabbit Polyclonal ELISA 10930-RP01
    Anti-FCN1 Antibody Mouse Monoclonal ELISA(Det) 10930-MM06
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