FAM3D Protein

Family with sequence similarity 3, member D

FAM3D Products

FAM3D Protein, Recombinant

Molecule	Species	Description	Cat. No
FAM3D	Human	FAM3D Protein, Recombinant	11659-H08H

FAM3D cDNA Clone

Molecule	Species	Description	Cat. No
FAM3D	Human	Homo sapiens FAM3D cDNA Clone	HG11659-M
FAM3D	Mouse	Mouse FAM3D cDNA Clone / ORF Clone	MG50951-G

FAM3D Alternative Names

FAM3D, UNQ567/PRO1130, EF7, OIT1 [Homo sapiens]

Fam3d, Oit1, 2310076N21Rik, AV067083, EF-7, MGC37550 [Mus musculus]

FAM3D Background

Family with sequence similarity 3 (FAM3) family is a novel cytokine-like gene family, which has four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy.

FAM3D Related Studies

1. Zhu Y, et al. (2002) Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics. 80(2): 144-50.
2. Katahira T, et al. (2010) Secreted factor FAM3C (ILEI) is involved in retinal laminar formation. Biochem Biophys Res Commun. 392(3): 301-6.
3. Shimada M, et al. (2010) An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Hum Genet. 128(4): 433-41.