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FABP6/ILBP/I-BABP Protein, Antibody, ELISA Kit, cDNA Clone

FABP6/ILBP/I-BABP Related Areas

FABP6/ILBP/I-BABP Related Pathways

FABP6/ILBP/I-BABP Related Product

    FABP6/ILBP/I-BABP Summary & Protein Information

    FABP6/ILBP/I-BABP Background

    Gene Summary: This FABP6 gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
    Subcellular location: Isoform 1: Cytoplasm.
    Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.
    Tissue specificity: Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
    Induction: Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up- regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.
    Sequence similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
    General information above from UniProt

    Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. FABP6 / I-BABP is a cancer-related protein that acts as an intracellular transporter of bile acid in the ileal epithelium. FABP6 / I-BABP may also play an important role in early carcinogenesis.

    FABP6/ILBP/I-BABP Alternative Name

    FABP6,I-15P,I-BABP,I-BALB,I-BAP,ILBP,ILLBP, [human]
    Fabp6,I-15P,I-BABP,ILBP,ILBP3,Illbp,RP23-26M1.3, [mouse]

    FABP6/ILBP/I-BABP Related Studies

  • Kurz M., et al., 2003, Proteins 50:312-328.
  • Ohmachi,T. et al., 2006, Clin Cancer Res.12 (17):5090-5.
  • Fang C., et al., 2007, Cancer Res. 67:9039-9046.
  • Szczerbal,I. et al., 2007, Cytogenet Genome Res.118 (1):63-6.
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