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FABP5/E-FABP Protein, Antibody, ELISA Kit, cDNA Clone

FABP5/E-FABP Related Areas

FABP5/E-FABP Related Pathways

FABP5/E-FABP Related Product

    FABP5/E-FABP Summary & Protein Information

    FABP5/E-FABP Background

    Gene Summary: This FABP5 gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]
    General information above from NCBI
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
    Subcellular location: Cytoplasm.
    Tissue specificity: Keratinocytes; highly expressed in psoriatic skin.
    Sequence similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.C
    General information above from UniProt

    Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins ( FABPs ) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP / FABP5 is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue characteristic of psoriasis and wound healing. E-FABP / FABP5 exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport. E-FABP / FABP5 has high specificity for fatty acids. It has highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity of FABP5. E-FABP / FABP5 may be involved in keratinocyte differentiation.

    FABP5/E-FABP Alternative Name

    EFABP,E-FABP,FABP5,PA-FABP,PAFABP, [human]
    E-FABP,Fabp5,Fabpe,Klbp,mal1,PA-FABP, [mouse]

    FABP5/E-FABP Related Studies

  • Hohoff C., et al., 1999, Biochemistry 38:12229-39
  • Gutierrez-Gonzalez L.H., et al., 2002, Biochem. J. 364:725-37.
  • Ogawa,E. et al., 2011, J Invest Dermatol. 131 (3):604-12.
  • Ma,X. et al., 2010, Mol Biol Rep. 37 (8):4003-11.
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