FABP4 (ALBP, A-FABP)

FABP4 is involved in lipid transport protein in adipocytes. FABP4 binds both long chain fatty acids and retinoic acid. FABP4 delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

FABP4 (ALBP, A-FABP) Related Areas

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Adipogenesis Marker>>FABP4/ALBP/A-FABP

Cardiovascular>>Lipid Metabolism>>FABP4/ALBP/A-FABP

FABP4 (ALBP, A-FABP) Alternative Names

FABP4, ALBP, A-FABP, AFABP, aP2 [Homo sapiens]

Fabp4, ALBP, A-FABP, AFABP, Ap2, 422/aP2, ALBP/Ap2, Lbpl, P15 [Mus musculus]

Summaries for FABP4 (ALBP, A-FABP)

Entrez Gene summary for FABP4:

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP4 is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

OMIM - description for FABP4:

FABP4, or AP2, functions as a cytosolic lipid chaperone in macrophages and is involved in regulating macrophage endoplasmic reticulum (ER) stress (Erbay et al., 2009).

Wikipedia summary for FABP4:

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking FABP4 either through genetic engineering or drugs has the possibility of treating heart disease, diabetes, asthma, obesity, and fatty liver disease.

Human FABP4 (ALBP, A-FABP) Protein General Information

 

• Protein names: Fatty acid-binding protein, adipocyte
• Sequence length: 132 AA.
• Domain: FABP4 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
• Sequence similarities: FABP4 belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
• Subunit structure: Homodimer. Interacts with PPARG. Monomer.
• Subcellular location: Cytoplasm. Nucleus. Note: Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export

General information above from UniProt

Function for FABP4 (ALBP, A-FABP) Protein

UniProtKB:

FABP4 is involved in lipid transport protein in adipocytes. FABP4 binds both long chain fatty acids and retinoic acid. FABP4 delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

Genatlas:

• fatty acid-binding protein 4, FABP4 is involved in lipid transport protein in adipocytes
• FABP4 with hormone-sensitive lipase (LIPE), form a physical complex that affects basal and hormone-stimulated adipocyte fatty acid efflux ((Smith 2008)
• FABP4 has a role as a fatty acid sensor affecting cellular metabolism via protein-protein interactions (Thompson 2009)
• fatty acid carrier solubilizing and enabling diffusion of fatty acids throughout the aqueous cellular environment (Thompson 2009)