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FABP4 / ALBP / A-FABP Antibody, Rabbit PAb, Antigen Affinity Purified

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Human FABP4 Antibody Product Information
Immunogen:Recombinant Human FABP4 / ALBP / A-FABP protein (Catalog#12109-H07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human FABP4 / ALBP / A-FABP (rh FABP4 / ALBP / A-FABP; Catalog#12109-H07E; P15090; Cys2-Ala 132, 29Ala /Thr ). FABP4 / ALBP / A-FABP specific IgG was purified by Human FABP4 / ALBP / A-FABP affinity chromatography.
Human FABP4 Antibody Usage Guide
Specificity:Human FABP4 / ALBP / A-FABP
Application:WB, ELISA, IP

WB: 2-5 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human FABP4. The detection limit for Human FABP4 is approximately 0.039 ng/well.

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human FABP4 Antibody WB Application Image
Human FABP4 Antibody IP Application Image
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          FABP4 /A-FABP Background

          Mouse fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

          Human FABP4 /A-FABP References
        • van Dongen,M.J. et al., 2002, J Am Chem Soc. 124 (40): 11874-80.
        • Coll, B. et al., 2008, Atherosclerosis  199 (1):147-53.
        • Hoashi,S. et al., 2008, BMC Genet. 9 :84.
        • Cai,H. et al., 2010, Bioorg Med Chem Lett  20 (12):3675-9.
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          Size / Price
          Catalog: 12109-RP02-200
          List Price: 
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"