FABP3 (H-FABP)

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

FABP3 (H-FABP) Related Areas

Cardiovascular>>Lipid Metabolism>>FABP3/H-FABP

FABP3 (H-FABP) Alternative Names

FABP3, H-FABP, FABP11, MDGI, O-FABP [Homo sapiens]

Fabp3, H-FABP, RP23-462N15.1, Fabph-1, Fabph-4, Fabph1, Fabph4, Mdgi [Mus musculus]

Summaries for FABP3 (H-FABP)

Entrez Gene summary for FABP3:

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This FABP3 gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]

Wikipedia summary for FABP3:

Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene.

Human FABP3 (H-FABP) Protein General Information

 

• Protein names: Heart-type fatty acid-binding protein, Short name=H-FABP
• Sequence length: 133 AA.
• Domain: FABP3 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
• Sequence similarities: FABP3 belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
• Subcellular location: Cytoplasm.

General information above from UniProt

Function for FABP3 (H-FABP) Protein

UniProtKB:

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Genatlas:

• FABP3 is fatty acid binding protein, tumor suppressor for breast cancer
• FABP3 participates in the uptake, intracellular metabolism and/or transport of long-chain fatty acids
• FABP3 supports potentially fat accumulation in the hypoxic placenta
• support plays important roles in the regulation of the hearing function
• support is heart-type fatty acid-binding protein, essential for cold tolerance and efficient fatty acid oxidation, in brown adipose tissue

Homology for human FABP3 (H-FABP)

• homolog to murine Fabp3