FABP2 / I-FABP Protein

Fatty Acid Binding Protein 2, Intestinal

FABP2 / I-FABP Products

FABP2 / I-FABP Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No	Price / Size
FABP2 / I-FABP	Human	FABP2/I-FABP Protein, Recombinant	10130-H08E	$300 / 200µg

FABP2 / I-FABP cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No	Price / Size
FABP2 / I-FABP	Human	Homo sapiens FABP2/I-FABP cDNA Clone	HG10130-M	$95

FABP2 / I-FABP Related Areas

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>FABP2/I-FABP

Cardiovascular>>Lipid Metabolism>>FABP2/I-FABP

FABP2 / I-FABP Alternative Names

FABP2, I-FABP, FABPI, MGC133132 [Homo sapiens]

Fabp2, I-FABP, Fabpi [Mus musculus]

FABP2 / I-FABP Background

Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the absorption and intracellular transport of dietary long chain fatty acids. The FABP2 gene is proposed as a candidate gene for diabetes because the protein it codes is involved in fatty acid (FA) absorption and metabolism and may, therefore, affect insulin sensitivity and glucose metabolism. Numerous studies have assessed FABP2 gene variants and their association with insulin resistance and type 2 diabetes. A transition of G to A at codon 54 of FABP2 results in an amino acid substitution (Ala54 to Thr54), which is common in diverse populations and results in increased FA absorption in vivo. Some evidence indicates that this variant may be associated with insulin sensitivity/type 2 diabetes. This polymorphism was associated with some cardiovascular risk factors. The cytosolic human intestinal fatty acid binding protein (hFABP2) is proposed to be involved in intestinal absorption of long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

FABP2 / I-FABP Related Studies

1. De Luis DA, et al. (2010) Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on insulin resistance and adipocytokines in patients with diabetes mellitus type 2. Eur Rev Med Pharmacol Sci. 14(2): 89-95.
2. Aller R, et al. (2009) Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on histological alterations and insulin resistance of non alcoholic fatty liver disease. Eur Rev Med Pharmacol Sci. 13(5): 357-64.
3. de Luis DA, et al. (2007) Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factors. Horm Metab Res. 39(11): 830-4.
4. Klapper M, et al.. (2007) The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4alpha. Biochem Biophys Res Commun. 356(1): 147-52.
5. Weiss EP, et al. (2002) Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effects. Physiol Genomics. 10(3): 145-57.