|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Rattus norvegicus F11 receptor DNA.|
|Identical with the Gene Bank Ref. ID sequence except for the point mutation 132 T/C not causing the amino acid variation.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Rat F11R Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||RG80240-G-F|
|Rat F11R Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||RG80240-G-H|
|Rat F11R Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||RG80240-G-M|
|Rat F11R Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||RG80240-G-N|
|Rat F11R Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||RG80240-G-Y|
|Product name||Product name|
Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.