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>Human Cell Expressed
>Rat F11R / JAM-A / JAM-1 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
F11 receptor Protein Datasheet
F11R / JAM-A / JAM-1 Protein Price Inquiry ( Available Sizes )
F11R / JAM-A / JAM-1 Protein Product Information
|Synonym :||F11R, Jam1|
A DNA sequence encoding the rat F11R (Q9JHY1)(Met1-Gly238) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
F11R / JAM-A / JAM-1 Protein QC Testing
|Purity:||> (23.7+75.2) % as determined by SDS-PAGE||SDS-PAGE:
F11R / JAM-A / JAM-1 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Lys 27|
The recombinant rat F11Rcomprises 223 amino acids and predicts a molecular mass of 24.3 kDa. The apparent molecular mass of the recombinant protein is approximately 28 and 32 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
F11R / JAM-A / JAM-1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
F11R / JAM-A / JAM-1 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|JAM-A/F11R/CD321||Human||JAM-A/F11R/Fc Protein, Recombinant||10198-H02H|
|JAM-A/F11R/CD321||Human||JAM-A/F11R Protein, Recombinant||10198-H08H|
|JAM-A/F11R||Mouse||JAM-A/F11R/Fc Protein, Recombinant||50463-M02H|
|JAM-A/F11R||Rat||F11R / JAM-A / JAM-1 Protein, Recombinant||80240-R02H|
|JAM-A/F11R||Rat||F11R / JAM-A / JAM-1 Protein, Recombinant||80240-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|ELISA||Mouse Monoclonal Antibody||10198-MM02|
|WB||Mouse Monoclonal Antibody||10198-MM03|
|FCM||JAM-A / F11R / CD321 Antibody ( FITC )||10198-MM04-F|
|FCM||JAM-A / F11R / CD321 Antibody ( PE )||10198-MM04-P|
|ELISA||Rabbit Polyclonal Antibody||10198-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10198-RP04|
F11R / JAM-A / JAM-1 Protein Description
Junctional adhesion molecule A, also known as Junctional adhesion molecule 1, Platelet F11 receptor, JAM-1, Platelet adhesion molecule 1, JAM-A, PAM-1, CD321 and F11R, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and Junctional Adhesion Molecule (JAM) family. JAM-A / CD321 is the firstly identified member of the JAM family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea.
- Williams LA. et al., 1999, Mol Immunol. 36: 1175-88.
- Sobocka MB. et al., 2000, Blood. 95: 2600-9.
- Babinska A. et al., 2002, Thromb Haemost. 88: 843-50.
- Ostermann G. et al., 2002, Nat Immunol. 3: 151-8.
- Kenneth J. et al., 2005, J Biol Chem. 280: 11665-74.
- Bazzoni G. et al., 2003, Curr Opin Cell Biol. 15: 525-30.
- Barton ES. et al., 2001, Cell. 104 : 441-51.