Sino Biological offers a comprehensive set of tools for research on extracellular matrix molecules, including recombinant proteins, antibodies (rabbit mAb, mouse mAb and rabbit pAb), ELISA kits and cDNA clones.
Most of the cells in multicellular organisms are surrounded by a complex mixture of nonliving material that makes up the extracellular matrix (ECM
). The extracellular matrix forms a supporting framework to help hold cells and tissues together. In vertebrates the extracellular matrix is composed of an interlocking mesh of proteins and glycosaminoglycans. Almost all of the proteins are glycoproteins, including collagens, elastins, fibronectin, laminins, etc. Proteoglycans are also glycoproteins but consist of much more carbohydrate than protein. Main types of proteoglycan found within the extracellular matrix are heparan sulfate, chondroitin sulfate and keratan sulfate. Some extracellular matrix components include hyaluronic acid (hyaluronate or HA), which confers upon tissues the ability to resist compression by providing a counteracting turgor force. Except for the foremost function as structural support to cells, the extracellular matrix also performs various other functions. In animals, it provides an organized environment within which migratory cells can move and interact with one another in orderly ways. The extracellular matrix (ECM
) is involved in diverse normal processes including embryonic development, cell adhesion, cell migration, tissue regeneration, as well as in multiple disease states including inflammation, atherosclerosis, and tumorigenesis.