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Escherichia coli acnB Antibody, Rabbit PAb, Antigen Affinity Purified

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    E. coli acnB Antibody Product Information
    Immunogen:Recombinant Escherichia coli acnB protein (Catalog#13102-ENAE)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Escherichia coli acnB (Catalog#13102-ENAE; Met 1-Val 865). Escherichia coli acnB specific IgG was purified by Escherichia coli acnB affinity chromatography.
    Other acnB Antibody Products
    acnB Background

    Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-aconitate as well as the dehydration of 2-methylisocitrate to cis-2-methylaconitate, thus it functions as the major citric-acid-cycle enzyme during exponential growth. Escherichia coli acnB serves as either an enzymic catalyst or a mRNA-binding post-transcriptional regulator, depending on the status of its iron sulfur cluster. AcnB represents a large, distinct group of Gram-negative bacterial aconitases that have an altered domain organization relative to mitochondrial aconitase and other aconitases.

    E. coli acnB References
  • Bradbury AJ. et al., 1996, 142 (Pt 2): 389-400.
  • Cunningham L. et al., 1997, Microbiology. 143 (Pt 12): 3795-805.
  • Jordan PA. et al., 1999, Biochem J. 344 Pt 3: 739-46.
  • Williams CH. et al., 2002, Nat Struct Biol. 9(6): 447-52.
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