Erythropoietin / EPO Protein & Antibody

Erythropoietin / EPO Products

Erythropoietin / EPO Protein, Recombinant

Molecule	Species	Description	Cat. No
Erythropoietin/EPO	Rat	Erythropoietin/EPO Protein, Recombinant	80055-R08B

Erythropoietin / EPO Antibody

Molecule	Application	Description	Cat. No
Rat Erythropoietin/EPO	WB, ELISA	Erythropoietin / EPO Antibody (Antigen Affinity Purified)	80055-RP02

Erythropoietin / EPO cDNA Clone

Molecule	Species	Description	Cat. No
Erythropoietin/EPO	Rat	Erythropoietin/EPO cDNA Clone / ORF Clone	RG80055-M
Erythropoietin/EPO	Cynomolgus	Cynomolgus monkey EPO cDNA Clone / ORF Clone	KG90133-G

Erythropoietin / EPO Related Areas

Cardiovascular>>Red Blood Cell>>Erythropoietin/EPO

Cancer>>Growth Factor & Receptor>>Other>>Erythropoietin/EPO

Erythropoietin / EPO Alternative Names

Erythropoietin, EPO, EP, MGC138142, MVCD2 [Homo sapiens]

Erythropoietin, Epo, OTTMUSP00000024624, OTTMUSP00000024625, OTTMUSP00000024626 [Mus musculus]

Erythropoietin, Epo [Rattus norvegicus]

Erythropoietin / EPO Background

Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. It is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. It has a longer circulating half-life in vivo. It is available under the name Aranesp (Amgen). Erythropoietin is being much misused as a performance-enhancing drug in endurance athletes.

Erythropoietin / EPO Related Studies

1. Jelkmann W, et al. (2007) Erythropoietin after a century of research: younger than ever. Eur J Haematol. 78 (3):183-205.
2. Miyake T, et al. (1997) Purification of human erythropoietin. J Biol Chem. 252(15):5558-64.
3. Haroon ZA, et al. (2003) A novel role for erythropoietin during fibrin-induced wound-healing response. Am J Pathol. 163(3):993-1000.
4. Siren AL, et al. (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci. 98(7):4044-9.