ErbB4 Protein (HER4 Protein)

Human Epidermal Growth Factor Receptor 4

ErbB4 Products

ErbB4 Protein, Recombinant

Molecule	Species	Description	Cat. No
ErbB4/HER4	Human	ErbB4/HER4/Fc Protein, Recombinant	10363-H03H

  10363-H03H:  Measured by its ability to bind with human NRG1-β1 in a functional ELISA.

ErbB4 cDNA Clone

Molecule	Species	Description	Cat. No
ErbB4/HER4	Human	Homo sapiens ErbB4/HER4 transcript variant JM-a/CVT-2 cDNA Clone(NM_001042599.1)	HG10363-M

Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>ErbB4/HER4

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>ErbB4/HER4

Cancer>>Cancer Biomarkers>>ErbB4/HER4

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>ErbB4/HER4

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>ErbB4/HER4

Alternative Names

ERBB4, HER4, MGC138404, p180erbB4 [Homo sapiens]

Erbb4, AC167658.1 [Mus musculus]

ErbB4 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
EGF	Human	EGF/Fc Protein, Recombinant
EGFR/HER1/ErbB1	Human	EGFR/HER1/ErbB1/Fc Protein, Recombinant (Met 1 - Ser 645)
EGFR/HER1/ErbB1	Human	EGFR/HER1/ErbB1 Protein, Recombinant (Met 1 - Ser 645)
EGFR/ErbB/HER1	Human	EGFR/HER1/ErbB1 Protein, Recombinant (Met 1 - Lys 642)
HER2/ErbB2	Human	HER2/ErbB2/Fc Protein, Recombinant
HER2/ErbB2	Human	HER2/ErbB2 Protein, Recombinant
HER2/ErbB2	Mouse	HER2/ErbB2 Protein, Recombinant
HER2/ErbB2	Rat	HER2/Fc Protein, Recombinant
HER2/ErbB2	Rat	HER2 Protein, Recombinant
HER2/ErbB2	Rat	HER2 Protein, Recombinant
HER2/ErbB2	Rhesus	HER2/Fc Protein, Recombinant
HER2/ErbB2	Rhesus	HER2 Protein, Recombinant
HER3/ErbB3	Human	HER3/ErbB3/Fc Protein, Recombinant
HER3/ErbB3	Human	HER3/ErbB3 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human HER2/ErbB2	ELISA	Mouse Monoclonal antibody
Human HER2/ErbB2	ELISA	Mouse Monoclonal Antibody (Biotin conjugated)
Human HER2/ErbB2	WB	Mouse Monoclonal Antibody (Biotin conjugated)
Human HER2/ErbB2	WB, ELISA, Flow Cytometry	HER2/ErbB2 Antibody, Rabbit MAb
Human HER2/ErbB2	WB, ELISA, IHC, Flow Cytometry	HER2/ErbB2 Antibody, Rabbit MAb
Human HER2/ErbB2	Flow Cytometry	ErbB2/HER2 Antibody, Rabbit MAb
Human HER2/ErbB2	WB, ELISA	Rabbit Polyclonal Antibody
Human HER2/ErbB2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human HER3/ErbB3	WB, ELISA	HER3/ErbB3 Antibody, Rabbit PAb
Human HER3/ErbB3	WB, ELISA	HER3/ErbB3 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Amphiregulin/AREG	Human	Homo sapiens Amphiregulin /AREG cDNA Clone(NM_001657.2)
EGF-L6	Human	Homo sapiens EGF-L6 cDNA Clone(NM_015507.2)
EGFR/ErbB1/HER1	Human	Homo sapiens EGFR/HER1/ErbB1 cDNA Clone
HB-EGF	Human	Homo sapiens HB-EGF cDNA Clone(NM_001945.2)
HER2/ErbB2	Human	Homo sapiens HER2/ErbB2 transcript variant 1 cDNA Clone(NM_004448.2)
HER2/ErbB2	Mouse	Mouse HER2/ErbB2 cDNA Clone / ORF Clone
HER2/ErbB2	Rat	Rat HER2/ErbB2 cDNA Clone / ORF Clone
HER2/ErbB2	Rhesus	Rhesus monkey HER2/ErbB2 cDNA Clone / ORF Clone
HER3/ErbB3	Human	Homo sapiens HER3/ErbB3 transcript variant 1 cDNA Clone(NM_001982.2)

ErbB4 Background

ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.

ErbB4 Related Studies

1. Huang, Y Z, et al. (2000) Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 26(2):443-55.
2. Garcia, R A, et al. (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci. 97(7):3596-601.
3. Silberberg G, et al. (2006) The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet. 141(B2):142-8.
4. Sardi SP, et al. (2006) Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 127(1):185-97.