Anti-HER3 / ERBB3 Antibody (FITC)

Cat: 10201-MM03-F
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Anti-HER3 / ERBB3 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-HER3 / ERBB3 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human HER3 / ERBB3
Immunogen
Recombinant Human ErbB3 / HER3 protein (Catalog#10201-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ErbB3 / HER3 (rh ErbB3 / HER3; Catalog#10201-H08H; NP_001973.2; Met1-Thr643) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #03
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-HER3 / ERBB3 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HER3 / ERBB3 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human EEBB3/HER3 Flow Cytometry (FC) 5181
Flow cytometric analysis of anti-Human ErbB3 on MCF-7 cells.
Anti-HER3 / ERBB3 Antibody (FITC) Alternative Names
Anti-c-erbB-3 Antibody;Anti-c-erbB3 Antibody;Anti-EEBB3 Antibody;Anti-ErbB-3 Antibody;Anti-erbB3-S Antibody;Anti-HER3 Antibody;Anti-LCCS2 Antibody;Anti-MDA-BF-1 Antibody;Anti-p180-ErbB3 Antibody;Anti-p45-sErbB3 Antibody;Anti-p85-sErbB3 Antibody
HER3 / ERBB3 Background Information

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 3
References
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 90043-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 90043-RP01
    Anti-HER3 / ERBB3 Antibody Mouse Monoclonal ELISA 90043-MM05
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 80111-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 80111-RP01
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA(Cap) 51003-R128
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA 51003-R028
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 51003-R138
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 51003-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 51003-RP01
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-mh908
    Anti-HER3 / ERBB3 Antibody (PE) Mouse Monoclonal FCM 10201-MM03-P
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-mhA24
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-MA24
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA 10201-R016
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-M908
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA,IHC-P 10201-T24
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 10201-RP01
    Anti-HER3 / ERBB3 Antibody (APC) Mouse Monoclonal FCM 10201-MM03-A
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 10201-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal WB,ELISA,IP 10201-RP02
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA(Det) 10201-R015
    Anti-HER3 / ERBB3 Antibody Mouse Monoclonal ELISA 10201-MM01
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