Anti-Her2 / ERBB2 Antibody (FITC)

Cat: 10004-MM03-F
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Anti-Her2 / ERBB2 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-Her2 / ERBB2 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Her2 / ERBB2
Immunogen
Recombinant Human ErbB2 protein (Catalog#10004-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ErbB2 / HER2 / CD340 (rh ErbB2 / HER2 / CD340; Catalog#10004-H08H; NP_004439.2; Met 1-Thr 652) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #9G1D4B10
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Her2 / ERBB2 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Her2 / ERBB2 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human HER2/ERBB2 Flow Cytometry (FC) 5400
Flow cytometric analysis of anti-Human ErbB2 on MCF-7 cells.
Anti-Her2 / ERBB2 Antibody (FITC) Alternative Names
Anti-CD340 Antibody;Anti-HER-2 Antibody;Anti-HER-2/neu Antibody;Anti-HER2 Antibody;Anti-MLN 19 Antibody;Anti-MLN19 Antibody;Anti-NEU Antibody;Anti-NGL Antibody;Anti-TKR1 Antibody
Her2 / ERBB2 Background Information

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 2
References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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