Epiregulin / EREG Protein

Epiregulin / EREG Products

Epiregulin / EREG Protein, Recombinant

Molecule	Species	Description	Cat. No
Epiregulin/EREG	Human	Epiregulin/EREG Protein, Recombinant	10677-H01H
Epiregulin/EREG	Mouse	Epiregulin/EREG Protein, Recombinant	50599-M01H

Epiregulin / EREG cDNA Clone

Molecule	Species	Description	Cat. No
Epiregulin/EREG	Human	Human Epiregulin/EREG cDNA Clone / ORF Clone	HG10677-M
Epiregulin/EREG	Mouse	Mouse Epiregulin/EREG cDNA Clone / ORF Clone	MG50599-M

Epiregulin / EREG Related Areas

Cancer>>Cancer Biomarkers>>Epiregulin/EREG

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>Epiregulin/EREG

Epiregulin / EREG Alternative Names

Epiregulin, EREG, ER, proepiregulin [Homo sapiens]

Ereg, EREG, EPR, MGC36144, proepiregulin [Mus musculus]

Epiregulin / EREG Background

Epiregulin (EREG) is a member of the epidermal growth factor family. Epiregulin (EREG) can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. Epiregulin (EREG) exhibit bifunctional regulatory properties: it inhibit the growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various other types of cells. Epiregulin (EREG) bound to the EGF receptors of epidermoid carcinoma A431 cells much more weakly than did EGF, but was nevertheless much more potent than EGF as a mitogen for rat primary hepatocytes and Balb/c 3T3 A31 fibroblasts. These findings suggest that epiregulin (EREG) plays important roles in regulating the growth of epithelial cells and fibroblasts by binding to receptors for EGF-related ligands. Epiregulin (EREG) is the broadest specificity EGF-like ligand so far characterized: not only does it stimulate homodimers of both ErbB-1 and ErbB-4, it also activates all possible heterodimeric ErbB complexes.

Epiregulin / EREG Related Studies

1. Shelly M, et al. (1998) Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem. 1998 Apr 24;273(17):10496-505.
2. Shirakata Y, et al. (2000) Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem. 275(8): 5748-53.
3. Zhu Z, et al. (2000) Epiregulin is Up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth. Biochem Biophys Res Commun. 273(3): 1019-24.