>Ephrin & Eph Receptor
Ephrin & Eph Receptor
Sino biological offers a comprehensive set of tools for research on ephrins and Eph receptors, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones. Eph receptors interact with ephrin ligands, their interaction would result in downstream signaling, involved in a number of biological processes including cell migration, cell-cell interaction, cell morphology, angiogenesis and cancer. Recent studies also indicated other potential roles of Ephrins and Eph receptors in development. There are currently 16 Eph receptors and 9 ephrins.
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Ephrin & Eph Receptor Background
Eph receptors belong to the receptor of tyrosine kinase (RTK) family which are a group of high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Eph receptors form the largest subgroup of the RTK family. Eph receptors interact with ephrin ligands, and their interaction would result in bi-directional signaling. There are currently 16 Eph receptors and 9 ephrins. Ephrins and Eph receptors play important roles in a number of biological processes, including cell migration, cell-cell interaction, cell morphology, angiogenesis and cancer. Recent studies also indicated other potential roles of Ephrins and Eph receptors in development. Ephrins and Eph receptors are emerging key players in synapse formation and plasticity in the central nervous system. Initial evidence of Eph receptors acting as axon guidance molecules were reported by Pasquale and colleagues. They found that EphB2, expressed in several regions of the chick and mouse brain, immunolocalised to the surface of growth cones for spinal motor and occulomotor neurons from their origin toward their targets. The Eph receptor is located on the neuron's growth cone, thus the cone grows toward a higher concentration of its ligand. Eph receptors are also expressed by cells found within the bone marrow microenvironment, including osteoblasts and osteoclasts, and there is increasing evidence to implicate this family of receptors in the control of normal and pathological bone remodeling.
Eph receptors are divided into two classes, based upon their interaction with ephrinA or ephrinB ligands. Eph receptors that bind to ephrinA ligands are referred to as EphA, and that bind to ephrinB ligands are referred to as EphB. But there is exception of EphA4 that can bind to ephrinA and ephrinB ligands, and ephrinA5 that can also bind to EphB2.
Ephrin & Eph Receptor Related Studies
- Pasquale EB, et al. (1992) Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. J Neurosci. 12(10):3956-67.
- Boyd AW, et al. (2001) Signals from Eph and ephrin proteins: a developmental tool kit. Sci STKE. 2001(112):re20.
- Ivanov AI, et al. (2006) Putative dual role of ephrin-Eph receptor interactions in inflammation. IUBMB Life. 58(7):389-94.
- Edwards CM, et al. (2008) Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci. 5(5):263-72.
- Lai KO, et al. (2009) Synapse development and plasticity: roles of ephrin/Eph receptor signaling. Curr Opin Neurobiol. 19(3):275-83.