Ephrin-B2 / EFNB2 Protein & Antibody

Ephrin-B2 / EFNB2 Products

Ephrin-B2 / EFNB2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant	10881-H03H
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant	10881-H08H
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2/Fc Protein, Recombinant	50598-M02H
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2 Protein, Recombinant	50598-M08H
Ephrin-B2/EFNB2	Rat	EFNB2 / EphrinB2 Protein, Recombinant	80107-R02H
Ephrin-B2/EFNB2	Rat	EFNB2 / EphrinB2 Protein, Recombinant	80107-R08H

  10881-H03H:

1. Immobilized human EphB4-his at 2 µg/ml (100 µl/well) can bind human EphrinB2 Fc chimera with a linear range of 1-25 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized human EphB4 at 2 µg/ml (100 µl/well) can bind human EphrinB2 Fc chimera with a linear range of 1-125 ng/ml. Measured by its binding ability in a functional ELISA.

  10881-H08H: Immobilized human EFNB2 at 2 μg/ml (100 μl/well) can bind human EphB4 with a linear ranger of  1.56 - 12.5 ng/ml. Measured by its binding ability in a functional ELISA.

  50598-M02H:  Immobilized mouse EphB4 at 2 µg/ml (100 µl/well) can bind mouse EphrinB2 Fc with a linear range of 0.2-25 ng/ml. Measured by its binding ability in a functional ELISA.

  50598-M08H  Measured by its ability to compete with mouse EFNB2-Fc for binding to immobilized mouse EPHB4 in a functional ELISA assay.

Ephrin-B2 / EFNB2 Antibody

Molecule	Application	Description	Cat. No
Mouse Ephrin-B2/EFNB2	WB, ELISA	Ephrin-B2/EFNB2 Antibody, Rabbit PAb	50598-RP01
Mouse Ephrin-B2/EFNB2	WB, ELISA	Ephrin-B2/EFNB2 Antibody, Rabbit PAb (Antigen Affinity Purified)	50598-RP02

Ephrin-B2 / EFNB2 cDNA Clone

Molecule	Species	Description	Cat. No
Ephrin-B2/EFNB2	Human	EphrinB2 cDNA Clone / ORF Clone	HG10881-M
Ephrin-B2/EFNB2	Mouse	EFNB2 cDNA Clone / ORF Clone	MG50598-M
Ephrin-B2/EFNB2	Rat	EFNB2 cDNA Clone / ORF Clone	RG80107-G

Ephrin-B2 / EFNB2 Alternative Names

Ephrin-B2, EFNB2, EPLG5, HTKL, Htk-L, LERK5, RP11-272L14.1, MGC126226, MGC126227, MGC126228[Homo sapiens]

ephrin-B2, Efnb2, ELF-2, Epl5, Eplg5, Htk-L, LERK-5, Lerk5, NLERK-1[Mus musculus]

Ephrin-B2 / EFNB2 Related Areas

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-B2/EFNB2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-B2/EFNB2

Ephrin-B2 / EFNB2 Related Products

Protein Products

Molecule	Species	Description
EphA4	Human	EphA4 Protein, Recombinant
EphA4	Mouse	EphA4/Fc Protein, Recombinant
EphA4	Mouse	EphA4 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA7	Human	EphA7 Protein, Recombinant
EphA7	Mouse	EphA7 Protein, Recombinant
EphB2	Human	EphB2/Fc Protein, Recombinant
EphB2	Human	EphB2 Protein, Recombinant
EphB4	Human	EphB4/Fc Protein, Recombinant
EphB4	Human	EphB4 Protein, Recombinant
EphB4	Human	EphB4 Protein, Recombinant
EphB4	Mouse	EphB4/Fc Protein, Recombinant
EphB4	Mouse	EphB4 Protein, Recombinant
EphB6	Human	EphB6/Fc Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A3/EFNA3	Mouse	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1/Fc Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human EphB2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human EphB4	WB	Mouse Monoclonal Antibody
Human EphB4	ELISA	Mouse Monoclonal Antibody
Human EphB4	WB, ELISA	Rabbit Monoclonal Antibody
Human EphB4	ELISA	Rabbit Polyclonal Antibody
Human EphB4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Ephrin-A1/EFNA1	WB, ELISA	Mouse Monoclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
EphA3	Human	Homo sapiens EphA3 cDNA Clone
EphA4	Human	Homo sapiens EphA4 cDNA Clone
EphA4	Mouse	Mus musculus EphA4 cDNA Clone
EphA6/EHK-2	Mouse	Mus musculus EphA6/EHK2 cDNA Clone
EphA7	Human	Homo sapiens EphA7 cDNA Clone
EphA7	Mouse	Mus musculus EphA7 cDNA Clone
EphB2	Human	Homo sapiens EphB2 cDNA Clone
EphB4	Human	Homo sapiens EphB4 cDNA Clone(NM_004444.4)
EphB4	Mouse	Mus musculus EphB4 cDNA Clone
EphB6	Human	Homo sapiens EphB6 cDNA Clone(NM_004445.2)
Ephrin-A1/EFNA1	Human	Homo sapiens Ephrin-A1/EFNA1 cDNA Clone(NM_004-428.2)
Ephrin-A3/EFNA3	Human	Homo sapiens Ephrin-A3/EFNA3 cDNA Clone(NM_004952.4)
Ephrin-A4/EFNA4	Human	Homo sapiens Ephrin-A4/EFNA4 cDNA Clone
Ephrin-A5/EFNA5	Human	Homo sapiens Ephrin-A5/EFNA5 cDNA Clone(NM_001962.1)
Ephrin-A5/EFNA5	Mouse	Mus musculus Ephrin-A5/EFNA5 cDNA Clone
Ephrin-B1/EFNB1	Human	Homo sapiens Ephrin-B1/EFNB1 cDNA Clone(NM_004429.4)
Ephrin-B1/EFNB1	Mouse	Mus musculus Ephrin-B1/EFNB1 cDNA Clone

Ephrin-B2 / EFNB2 Background

EphrinB2 also known as EFNB2 is a member of the ephrin family. EphrinB2 is involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. The transmembrane-associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall.

Ephrin-B2 / EFNB2 Related Studies

1. Wang HU, et al. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93(5): 741-53.
2. Gale NW, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230(2): 151-60.
3. Shin D, et al. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 230(2): 139-50.