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EFNB2/Ephrin-B2 Rabbit PAb , Antigen Affinity Purified

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    Mouse EphrinB2/EFNB2 Antibody Product Information
    Immunogen:Recombinant Mouse EFNB2 protein (Catalog#50598-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse EFNB2 (rM EFNB2; Catalog#50598-M08H; NP_034241.2; Met 1-Ala 232). EFNB2 specific IgG was purified by mouse EFNB2 affinity chromatography .
    Other EphrinB2/EFNB2 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10881-RP01-100
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      Application: ELISA  
        10881-T16-100
        10881-T16-50
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        Application: ELISA  IHC-P  
        • Slide 1
        50598-T24-100
        50598-T24-50
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        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50598-RP01-100
          50598-RP01-200
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          100 µg 
          200 µg 
           
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          Reactivity: Rat  
          Application: ELISA  
            80107-T16-100
            80107-T16-50
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            Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

            Lane A: NIH3T3 Whole Cell Lysate

            Lane B: Hela Whole Cell Lysate

            Lysates/proteins at 30 μg per lane.

            Secondary

            Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

            Developed using the ECL technique.

            Performed under reducing conditions.

            Predicted band size:15 kDa

            Observed band size:17 kDa

            EFNB2/Ephrin-B2 Background

            EphrinB2 also known as EFNB2 is a member of the ephrin family. EphrinB2 is involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. The transmembrane-associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall.

            Mouse EFNB2/Ephrin-B2 References
          • Wang HU, et al. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93(5): 741-53.
          • Gale NW, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230(2): 151-60.
          • Shin D, et al. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 230(2): 139-50.
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            Size / Price
            Catalog: 50598-RP02-50
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"