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Ephrin-B2 / EFNB2 Antibody, Rabbit PAb, Antigen Affinity Purified

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    Mouse EphrinB2/EFNB2 Antibody Product Information
    Immunogen:Recombinant Mouse EFNB2 protein (Catalog#50598-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse EFNB2 (rM EFNB2; Catalog#50598-M08H; NP_034241.2; Met 1-Ala 232). EFNB2 specific IgG was purified by mouse EFNB2 affinity chromatography .
    Other EphrinB2/EFNB2 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10881-T16-50
      10881-T16-200
      10881-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10881-RP01-400
        10881-RP01-200
        10881-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  IHC-P  
        • Slide 1
        50598-T24-50
        50598-T24-200
        50598-T24-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50598-RP01-400
          50598-RP01-200
          50598-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart

          Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

          Lane A: NIH3T3 Whole Cell Lysate

          Lane B: Hela Whole Cell Lysate

          Lysates/proteins at 30 μg per lane.

          Secondary

          Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

          Developed using the ECL technique.

          Performed under reducing conditions.

          Predicted band size:15 kDa

          Observed band size:17 kDa

          EFNB2/Ephrin-B2 Background

          EphrinB2 also known as EFNB2 is a member of the ephrin family. EphrinB2 is involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. The transmembrane-associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall.

          Mouse EFNB2/Ephrin-B2 References
        • Wang HU, et al. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93(5): 741-53.
        • Gale NW, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230(2): 151-60.
        • Shin D, et al. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 230(2): 139-50.
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"