All Ephrin-B1 reagents are produced in house and quality controlled, including 5 Ephrin-B1 Antibody, 36 Ephrin-B1 Gene, 1 Ephrin-B1 IPKit, 6 Ephrin-B1 Lysate, 6 Ephrin-B1 Protein, 3 Ephrin-B1 qPCR. All Ephrin-B1 reagents are ready to use.
Recombinant Ephrin-B1 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-His, C-human IgG1-Fc.
Ephrin-B1antibodies are validated with different applications, which are ELISA, WB, IP.
Ephrin-B1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Ephrin-B1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Ephrin-B1 also known as EFNB1, is a member of the ephrin family. The transmembrane- associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB1 and B class Eph receptors provide positional cues required for the normal morphogenesis of skeletal elements. Another malformation, preaxial polydactyly, was exclusively seen in heterozygous females in which expression of the X-linked ephrinB1 gene was mosaic, so that ectopic EphB-ephrinB1 interactions led to restricted cell movements and the bifurcation of digital rays.