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Ephrin-B1/EFNB1 Protein, Antibody, ELISA Kit, cDNA Clone

Mouse Ephrin-B1/EFNB1 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50580-M02H-100
50580-M02H-200
100 µg / $100
200 µg / $150
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
50580-M08H-100
50580-M08H-200
100 µg / $90
200 µg / $150
Add to Cart

Rat Ephrin-B1/EFNB1 Protein

Expression host: Human Cells
  • Slide 1
80106-R08H-100
80106-R08H-200
100 µg / $210
200 µg / $350
Add to Cart
Expression host: Human Cells
  • Slide 1
80106-R02H-200
80106-R02H-500
200 µg / $140
500 µg / $290
Add to Cart

Human Ephrin-B1/EFNB1 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10894-H08H-5
10894-H08H-100
10894-H08H-200
5 µg / $38
100 µg / $200
200 µg / $300
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10894-H03H-50
10894-H03H-100
50 µg / $170
100 µg / $290
Add to Cart

Ephrin-B1/EFNB1 Related Areas

Ephrin-B1/EFNB1 Related Pathways

Ephrin-B1/EFNB1 Related Product

Ephrin-B1/EFNB1 Summary & Protein Information

Ephrin-B1/EFNB1 Related Information

Ephrin-B1/EFNB1 Background

Gene Summary: The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system
General information above from NCBI
Subunit structure: Interacts with GRIP1 and GRIP2.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.
Induction: By TNF.
Post-translational: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain (By similarity).
Involvement in disease: Craniofrontonasal syndrome (CFNS) [MIM:304110]: X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain.
General information above from UniProt

Ephrin-B1 also known as EFNB1, is a member of the ephrin family. The transmembrane- associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB1 and B class Eph receptors provide positional cues required for the normal morphogenesis of skeletal elements. Another malformation, preaxial polydactyly, was exclusively seen in heterozygous females in which expression of the X-linked ephrinB1 gene was mosaic, so that ectopic EphB-ephrinB1 interactions led to restricted cell movements and the bifurcation of digital rays.

Ephrin-B1/EFNB1 Alternative Name

Ephrin-B1/EFNB1 Related Studies

  • Davy A, et al. (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 18(5): 572-83.
  • Compagni A, et al. (2003) Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 5(2): 217-30.
  • Wieland I, et al. (2004) Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. Am J Hum Genet. 74(6): 1209-15.
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