Anti-Ephrin-B1 Antibody

Cat: 10894-RP02
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Anti-Ephrin-B1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Ephrin-B1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Ephrin-B1
Immunogen
Recombinant Human EFNB1 protein (Catalog#10894-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human EFNB1 (rh EFNB1; Catalog#10894-H08H; NP_004420.1; Met 1-Gly 232). EFNB1 specific IgG was purified by human EFNB1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Ephrin-B1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Ephrin-B1 Antibody Alternative Names
Anti-CFND Antibody;Anti-CFNS Antibody;Anti-EFB1 Antibody;Anti-EFL3 Antibody;Anti-Elk-L Antibody;Anti-EPLG2 Antibody;Anti-LERK2 Antibody
Ephrin-B1 Background Information

Ephrin-B1 also known as EFNB1, is a member of the ephrin family. The transmembrane- associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB1 and B class Eph receptors provide positional cues required for the normal morphogenesis of skeletal elements. Another malformation, preaxial polydactyly, was exclusively seen in heterozygous females in which expression of the X-linked ephrinB1 gene was mosaic, so that ectopic EphB-ephrinB1 interactions led to restricted cell movements and the bifurcation of digital rays.

Full Name
ephrin-B1
References
  • Davy A, et al. (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 18(5): 572-83.
  • Compagni A, et al. (2003) Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 5(2): 217-30.
  • Wieland I, et al. (2004) Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. Am J Hum Genet. 74(6): 1209-15.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Ephrin-B1 Antibody Rabbit Polyclonal ELISA 80106-RP01
    Anti-Ephrin-B1 Antibody Rabbit Polyclonal WB,ELISA,IP 80106-T52
    Anti-Ephrin-B1 Antibody Rabbit Polyclonal ELISA 50580-RP02
    Anti-Ephrin-B1 Antibody Rabbit Polyclonal ELISA 10894-RP01
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