Anti-Ephrin A5 Antibody

Cat: 10192-RP01
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Anti-Ephrin A5 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Ephrin A5 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Ephrin A5
Immunogen
Recombinant Human EphrinA5 protein (Catalog#10192-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human EphrinA5 (rhEphrinA5; Catalog#10192-H08H; NP_001953.1; Met 1-Asn 203). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Ephrin A5 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Ephrin A5 Antibody Alternative Names
Anti-AF1 Antibody;Anti-EFL5 Antibody;Anti-EPLG7 Antibody;Anti-GLC1M Antibody;Anti-LERK7 Antibody;Anti-RAGS Antibody
Ephrin A5 Background Information

Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Full Name
ephrin-A5
References
  • Frisén J, et al. (1998) Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20(2): 235-43.
  • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
  • Wahl S, et al. (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol. 149(2): 263-70.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Ephrin A5 Antibody Rabbit Polyclonal IHC-P 50597-T08
    Anti-Ephrin A5 Antibody Rabbit Polyclonal ELISA 10192-RP02
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