Ephrin-A4 / EFNA4 Protein

Ephrin-A4 / EFNA4 Products

Ephrin-A4 / EFNA4 Protein, Recombinant

Molecule	Species	Description	Cat. No
Ephrin-A4/EFNA4	Mouse	Ephrin-A4/EFNA4/Fc Protein, Recombinant	50595-M02H
Ephrin-A4/EFNA4	Mouse	Ephrin-A4/EFNA4 Protein, Recombinant	50595-M08H

  50595-M02H:

1. Immobilized human EphA7 at 2 µg/ml (100 µl/well) can bind mouse EphrinA4 Fc Chimera with a linear range of 0.08-10 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized mouse EphA7 at 2 µg/ml (100 µl/well) can bind mouse EphrinA4 Fc Chimera with a linear range of 0.08-10 ng/ml. Measured by its binding ability in a functional ELISA.

  50595-M08H:  Measured by its ability to compete mouse EFNA4 for binding to immobilized mouse EPHA7 in a functional ELISA.

Ephrin-A4 / EFNA4 cDNA Clone

Molecule	Species	Description	Cat. No
Ephrin-A4/EFNA4	Human	Homo sapiens Ephrin-A 4/EFNA4 cDNA Clone	HG12087-G
Ephrin-A4/EFNA4	Mouse	Mus musculus Ephrin-A4/EFNA4 cDNA Clone	MG50595-M

Ephrin-A4 / EFNA4 Related Areas

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-A4/EFNA4

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-A4/EFNA4

Ephrin-A4 / EFNA4 Alternative Names

Ephrin-A4, EFNA4, LERK-4, EFL4, EPLG4, FLJ57652, LERK4, MGC125826 [Homo sapiens]

Ephrin-A4, Efna4, EFL-4, Epl4, LERK-4 [Mus musculus]

Ephrin-A4 / EFNA4 Background

EPH-related receptor tyrosine kinase ligand 4 (Ephrin-A4) also known as EFNA4, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A4/EFNA4 functions as a cell surface GPI-bound ligand for Eph receptor, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.

Ephrin-A4 / EFNA4 Related Studies

1. Aasheim HC, et al. (2000) A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. Blood. 95(1): 221-30.
2. Moss A, et al. (2005) Ephrin-A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding. Eur J Neurosci. 22(10): 2413-21.
3. Cerretti DP, et al. (1998) Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. Genomics. 47(1): 131-5.