Ephrin-A3/EFNA3 Protein & Antibody

Ephrin-A3 / EFNA3 Products

Ephrin-A3 / EFNA3 Protein, Recombinant

Molecule	Species	Description	Cat. No
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant	10188-H02H
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant	10188-H03H
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant	10188-H08H
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant	10188-HCCH
Ephrin-A3/EFNA3	Mouse	Ephrin-A3/EFNA3 Protein, Recombinant	50594-M08H

 10188-H02H:  Immobilized mouse EphA6 at 1 µg/mL (100 µl/well) can bind human EphrinA3/Fc Chimera. The EC₅₀ of human EphrinA3 is 299.2 ng/mL.. Measured by its binding ability in a functional ELISA.

  10188-H08H: Measured by its ability to compete with human EphrinA3/Fc for binding to immobilized mouse EphA6-his in a functional ELISA assay.

  50594-M08H: Immobilized mouse EphrinA3 at 1 µg/ml (100 µl/well) can bind mouse EPHA6 with a linear ranger of 6.25-400 ng/ml. Measured by its binding ability in a functional ELISA.

Ephrin-A3 / EFNA3 Antibody

Molecule	Application	Description	Cat. No
Human Ephrin-A3/EFNA3	WB, ELISA	Ephrin-A3/EFNA3 Antibody, Rabbit PAb	10188-RP01
Human Ephrin-A3/EFNA3	WB, ELISA	Ephrin-A3/EFNA3 Antibody, Rabbit Pab (Antigen Affinity Purified)	10188-RP02

Ephrin-A3 / EFNA3 cDNA Clone

Molecule	Species	Description	Cat. No
Ephrin-A3/EFNA3	Human	Homo sapiens Ephrin-A3/EFNA3 cDNA Clone(NM_004952.4)	HG10188-M

Ephrin-A3 / EFNA3 Alternative Names

Ephrin-A3, EFNA3, EFL2, Ehk1-L, LERK3, EPLG3 [Homo sapiens]

Ephrin A3, Efna3, EFL-2, Ehk1-L, LERK-3, AW494418, Epl3, MGC129300, MGC129301 [Mus musculus]

Ephrin-A3 / EFNA3 Related Areas

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-A3/EFNA3

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-A3/EFNA3

Ephrin-A3 / EFNA3 Related Products

Protein Products

Molecule	Species	Description
EphA4	Human	EphA4 Protein, Recombinant
EphA4	Mouse	EphA4/Fc Protein, Recombinant
EphA4	Mouse	EphA4 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA7	Human	EphA7 Protein, Recombinant
EphA7	Mouse	EphA7 Protein, Recombinant
EphB2	Human	EphB2/Fc Protein, Recombinant
EphB2	Human	EphB2 Protein, Recombinant
EphB4	Human	EphB4/Fc Protein, Recombinant
EphB4	Human	EphB4 Protein, Recombinant
EphB4	Human	EphB4 Protein, Recombinant
EphB4	Mouse	EphB4/Fc Protein, Recombinant
EphB4	Mouse	EphB4 Protein, Recombinant
EphB6	Human	EphB6/Fc Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1/Fc Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2/Fc Protein, Recombinant
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human EphB2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human EphB4	WB	Mouse Monoclonal Antibody
Human EphB4	ELISA	Mouse Monoclonal Antibody
Human EphB4	WB, ELISA	Rabbit Monoclonal Antibody
Human EphB4	ELISA	Rabbit Polyclonal Antibody
Human EphB4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Ephrin-A1/EFNA1	WB, ELISA	Mouse Monoclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
EphA3	Human	Homo sapiens EphA3 cDNA Clone
EphA4	Human	Homo sapiens EphA4 cDNA Clone
EphA4	Mouse	Mus musculus EphA4 cDNA Clone
EphA6/EHK-2	Mouse	Mus musculus EphA6/EHK2 cDNA Clone
EphA7	Human	Homo sapiens EphA7 cDNA Clone
EphA7	Mouse	Mus musculus EphA7 cDNA Clone
EphB2	Human	Homo sapiens EphB2 cDNA Clone
EphB4	Human	Homo sapiens EphB4 cDNA Clone(NM_004444.4)
EphB4	Mouse	Mus musculus EphB4 cDNA Clone
EphB6	Human	Homo sapiens EphB6 cDNA Clone(NM_004445.2)
Ephrin-A1/EFNA1	Human	Homo sapiens Ephrin-A1/EFNA1 cDNA Clone(NM_004-428.2)
Ephrin-A4/EFNA4	Human	Homo sapiens Ephrin-A4/EFNA4 cDNA Clone
Ephrin-A5/EFNA5	Human	Homo sapiens Ephrin-A5/EFNA5 cDNA Clone(NM_001962.1)
Ephrin-A5/EFNA5	Mouse	Mus musculus Ephrin-A5/EFNA5 cDNA Clone
Ephrin-B1/EFNB1	Human	Homo sapiens Ephrin-B1/EFNB1 cDNA Clone(NM_004429.4)
Ephrin-B1/EFNB1	Mouse	Mus musculus Ephrin-B1/EFNB1 cDNA Clone
Ephrin-B2/EFNB2	Human	Homo sapiens Ephrin-B2/EFNB2 cDNA Clone(NM_004093.2)
Ephrin-B2/EFNB2	Mouse	Mus musculus EphrinB2/EFNB2 cDNA Clone

Ephrin-A3 / EFNA3 Background

Ephrin-A3 also known as EPH-related receptor tyrosine kinase ligand 3 or EFNA3, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A3 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: Ephrin-A3 ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A3 expressed on astrocytes activates EphA4 on the post-synaptic neuron and restricts the growth of dendritic spines through multiple pathways.

Ephrin-A3 / EFNA3 Related Studies

1. Klein R. (2009) Bidirectional modulation of synaptic functions by Eph/ephrin signaling. Nat Neurosci. 12(1): 15-20.
2. Lai KO, et al. (2009) Synapse development and plasticity: roles of ephrin/Eph receptor signaling. Curr Opin Neurobiol. 19(3): 275-83.
3. Prevost N, et al. (2002) Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A. 99(14): 9219-24.