Ephrin-A2 / EFNA2 Protein & Antibody

Ephrin-A2 / EFNA2 Products

Ephrin-A2 / EFNA2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Ephrin-A2/EFNA2	Mouse	Ephrin-A2/EFNA2 Protein, Recombinant	50579-M08H
Ephrin-A2/EFNA2	Mouse	Ephrin-A2/EFNA2 Protein, Recombinant	50579-MCCH

Ephrin-A2 / EFNA2 Antibody

Molecule	Application	Description	Cat. No
Mouse Ephrin-A2/EFNA2	WB, ELISA	Ephrin-A2 / EFNA2 Antibody	50579-RP01
Mouse Ephrin-A2/EFNA2	WB, ELISA	Ephrin-A2 / EFNA2 Antibody (Antigen Affinity Purified)	50579-RP02

Ephrin-A2 / EFNA2 cDNA Clone

Molecule	Species	Description	Cat. No
Ephrin-A2/EFNA2	Mouse	Mus musculus Ephrin-A2/EFNA2 cDNA Clone	MG50579-M
Ephrin-A2/EFNA2	Rat	EFNA2 cDNA Clone / ORF Clone	RG80110-G

Ephrin-A2 / EFNA2 Related Areas

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-A2/EFNA2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-A2/EFNA2

Ephrin-A2 / EFNA2 Alternative Names

Ephrin-A2, EFNA2, ELF-1, EPLG6, HEK7-L, LERK6 [Homo sapiens]

Ephrin-A2, Efna2, CEK7L, Elf1, Epl6, Eplg6, Lerk6 [Mus musculus]

Ephrin-A2 / EFNA2 Background

Ephrin-A2 also known as EFNA2 or EPH-related receptor tyrosine kinase ligand 6, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A2 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A2 regulates the position-specific affinity of limb mesenchyme and is involved in cartilage pattern formation in the limb.

Ephrin-A2 / EFNA2 Related Studies

1. Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
2. Jurney WM, et al. (2002) Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse. J Neurosci. 22(14): 6019-28.
3. Holmberg J, et al. (2005) Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev. 19(4): 462-71.