Anti-Ephrin-A1 Antibody

Cat: 10882-MM01
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Anti-Ephrin-A1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Ephrin-A1 Antibody
Validated applications
ELISA,ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human Ephrin-A1
No cross-reactivity in ELISA with Human EphrinA5 / EFNA5 Human EphrinA3 / EFNA3
Immunogen
Recombinant Human EFNA1 protein (Catalog#10882-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EphrinA1 (rh EphrinA1; Catalog#10882-H08H; NP_004419.2; Met 1-Ser 182). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #3F7H7F6
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Ephrin-A1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human Ephrin-A1 / EFNA1 in ELISA pair set (Catalog: # SEK10882). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10882-R114).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Ephrin-A1 Antibody Alternative Names
Anti-B61 Antibody;Anti-ECKLG Antibody;Anti-EFL1 Antibody;Anti-EFNA1 Antibody;Anti-EPLG1 Antibody;Anti-LERK-1 Antibody;Anti-LERK1 Antibody;Anti-TNFAIP4 Antibody
Ephrin-A1 Background Information

EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.

Full Name
ephrin-A1
References
  • Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
  • Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
  • Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Ephrin-A1 Antibody Rabbit Polyclonal ELISA 80115-RP01
    Anti-Ephrin-A1 Antibody Rabbit Polyclonal ELISA 50593-RP01
    Anti-Ephrin-A1 Antibody Rabbit Polyclonal ELISA 50593-RP02
    Anti-Ephrin-A1 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10882-R114
    Anti-Ephrin-A1 Antibody Rabbit Polyclonal ELISA,IHC-P 10882-RP02
    Anti-Ephrin-A1 Antibody Rabbit Polyclonal ELISA 10882-RP01
    Anti-Ephrin-A1 Antibody Rabbit Monoclonal IHC-P 10882-R453
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