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> EphB6 Protein & Antibody EphB6 Protein & Antibody
Eph receptor B6
EphB6 Products
EphB6 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| EphB6 | Human | EphB6/Fc Protein, Recombinant | 10197-H02H |
| EphB6 | Human | EphB6 Protein, Recombinant | 10197-H08H |
| EphB6 | Human | EphB6 Protein, Recombinant | 10197-HCCH |
EphB6 Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human EphB6 |
FCM | EphB6 Antibody ( FITC ) | 10197-MM05-F |
| Human EphB6 |
WB, ELISA | EphB6 Antibody, Mouse MAb | 10197-MM07 |
| Human EphB6 |
WB, ELISA | EphB6 Antibody, Rabbit PAb | 10197-RP01 |
| Human EphB6 |
WB, ELISA | EphB6 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10197-RP02 |
EphB6 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| EphB6 | Human | Homo sapiens EphB6 cDNA Clone(NM_004445.2) | HG10197-M |
| EphB6 | Rat | Rat EPHB6 Gene cDNA Clone / ORF Clone | RG80122-G |
EphB6 Related Areas
Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB6
Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB6
Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB6
Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB6
Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB6
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>EphB6
EphB6 Alternative Names
EphB6, HEP, MGC129910, MGC129911 [Homo sapiens]
Ephb6, Cekl, Mep [Mus musculus]
EphB6 Related Products
Protein Products
Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human EphB2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human EphB4 |
WB | Mouse Monoclonal Antibody |
| Human EphB4 |
ELISA | Mouse Monoclonal Antibody |
| Human EphB4 |
WB, ELISA | Rabbit Monoclonal Antibody |
| Human EphB4 |
ELISA | Rabbit Polyclonal Antibody |
| Human EphB4 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Mouse Monoclonal Antibody |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human Ephrin-A5/EFNA5 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human Ephrin-A5/EFNA5 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
cDNA Clone Products
EphB6 Background
Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.
EphB6 Related Studies
- Munthe E, et al. (2000)Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6.　FEBS Lett. 466(1): 169-74.
- Matsuoka H, et al. (2005) Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem. 280(32): 29355-63.
- Truitt L, et al. (2010) The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 70(3): 1141-53.
EphB6 related areas, pathways, and other information
