Anti-EphB6 Antibody (FITC)

Cat: 10197-MM05-F
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Anti-EphB6 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-EphB6 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human EphB6
No cross-reactivity in ELISA with Human EphB4 Human cell lysate (293 cell line)
Immunogen
Recombinant Human EphB6 protein (Catalog#10197-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EphB6 (rh EphB6; Catalog#10197-H08H; NP_004436.1; Met 1-Ser 579) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG2b Clone #05
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-EphB6 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphB6 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human EphB6/Eph Receptor B6 Flow Cytometry (FC) 2586
Profile of anti-Human EphB6 reactivity on Jurkat cells analyzed by flow cytometry.
Anti-EphB6 Antibody (FITC) Alternative Names
Anti-HEP Antibody
EphB6 Background Information

Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.

Full Name
EPH receptor B6
References
  • Munthe E, et al. (2000)Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett. 466(1): 169-74.
  • Matsuoka H, et al. (2005) Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem. 280(32): 29355-63.
  • Truitt L, et al. (2010) The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 70(3): 1141-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphB6 Antibody Rabbit Polyclonal IHC-P 51123-T08
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA,IHC-P 10197-T24
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA 10197-RP02
    Anti-EphB6 Antibody Mouse Monoclonal ELISA 10197-MM07
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA 10197-R037
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA(Det) 10197-R031
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA 10197-RP01
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA(Cap) 10197-R026
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