Anti-EphB6 Antibody

Cat: 10197-MM07
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All EphB6 Reagents
CRO Services
Product recommended

All EphB6 Reagents
Anti-EphB6 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-EphB6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human EphB6
Immunogen
Recombinant Human EphB6 protein (Catalog#10197-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EphB6 (rh EphB6; Catalog#10197-H08H; NP_004436.1; Met 1-Ser 579). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #4A9C4F2
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphB6 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphB6 Antibody Alternative Names
Anti-HEP Antibody
EphB6 Background Information

Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.

Full Name
EPH receptor B6
References
  • Munthe E, et al. (2000)Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett. 466(1): 169-74.
  • Matsuoka H, et al. (2005) Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem. 280(32): 29355-63.
  • Truitt L, et al. (2010) The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 70(3): 1141-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphB6 Antibody Rabbit Polyclonal IHC-P 51123-T08
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA,IHC-P 10197-T24
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA 10197-RP02
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA 10197-R037
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA(Det) 10197-R031
    Anti-EphB6 Antibody Rabbit Polyclonal ELISA 10197-RP01
    Anti-EphB6 Antibody Rabbit Monoclonal ELISA(Cap) 10197-R026
    info info
    添加购物车成功! 添加购物车失败!