EphB4 Protein & Antibody

Eph receptor B4

EphB4 Protein & Antibody

Sino biological offers a comprehensive set of tools for research on ephrin and Eph receptor. These include recombinant proteins, monoclonal/polyclonal antibodies and ORF cDNA clones.

EphB4 Protein, Recombinant

Molecule	Species	Description	Cat. No
EphB4	Human	EphB4/Fc Protein, Recombinant	10235-H02H
EphB4	Human	EphB4 Protein, Recombinant	10235-H08H
EphB4	Human	EphB4 Protein, Recombinant	10235-HCCH
EphB4	Mouse	EphB4/Fc Protein, Recombinant	50582-M02H
EphB4	Mouse	EphB4 Protein, Recombinant	50582-M08H

  10235-H02H: Immobilized human EFNB2 at 2 μg/ml (100 μl/well) can bind human EphB4-Fc with a linear ranger of 1.56 - 12.5 ng/ml. Measured by its binding ability in a functional ELISA.

  10235-H08H: Immobilized human EphB4 at 2 µg/ml (100 µl/well) can bind human EphrinB2 with a linear range of 1-25 ng/ml. Measured by its binding ability in a functional ELISA.

  10235-HCCH:  Immobilized human EphB4 at 2 µg/ml (100 µl/well) can bind human EphrinB2 with a linear range of 1-125 ng/ml. Measured by its binding ability in a functional ELISA.

  50582-H08H: Immobilized human EphB4 at 2 µg/ml (100 µl/well) can bind human EphrinB2 with a linear range of 0.2-25 ng/ml. Measured by its binding ability in a functional ELISA.

EphB4 Antibody

Molecule	Application	Description	Cat. No
Human EphB4	WB	Mouse Monoclonal Antibody	10235-MM03
Human EphB4	ELISA	Mouse Monoclonal Antibody	10235-MM04
Human EphB4	FCM	EphB4 Antibody ( FITC )	10235-MM04-F
Human EphB4	IHC	EphB4 Antibody, Mouse MAb	10235-MM05
Human EphB4	WB, ELISA	Rabbit Monoclonal Antibody	10235-RM02
Human EphB4	ELISA	Rabbit Polyclonal Antibody	10235-RP01
Human EphB4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10235-RP05
Mouse EphB4	WB, ELISA	EphB4 Antibody	50582-RP01
Mouse EphB4	WB, ELISA	EphB4 Antibody (Antigen Affinity Purified)	50582-RP02
Mouse EphB4	WB, ELISA	EphB4 Antibody	50582-R039

EphB4 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB4

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB4

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB4

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>EphB4

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB4

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB4

EphB4 Alternative Names

EphB4, HTK, MYK1, TYRO11 [Homo sapiens]

Ephb4, Htk, Myk1, Tyro11, AI042935, MDK2 [Mus musculus]

EphB4 Related Products

Protein Products

Molecule	Species	Description
EphA4	Human	EphA4 Protein, Recombinant
EphA4	Mouse	EphA4/Fc Protein, Recombinant
EphA4	Mouse	EphA4 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA6/EHK-2	Mouse	EphA6 /EHK2 Protein, Recombinant
EphA7	Human	EphA7 Protein, Recombinant
EphA7	Mouse	EphA7 Protein, Recombinant
EphB2	Human	EphB2/Fc Protein, Recombinant
EphB2	Human	EphB2 Protein, Recombinant
EphB6	Human	EphB6/Fc Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
EphB6	Human	EphB6 Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Human	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1/Fc Protein, Recombinant
Ephrin-A1/EFNA1	Mouse	Ephrin-A1/EFNA1 Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3/Fc Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A3/EFNA3	Human	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A3/EFNA3	Mouse	Ephrin-A3/EFNA3 Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Human	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5/Fc Protein, Recombinant
Ephrin-A5/EFNA5	Mouse	Ephrin-A5/EFNA5 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Human	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1/Fc Protein, Recombinant
Ephrin-B1/EFNB1	Mouse	Ephrin-B1/EFNB1 Protein, Recombinant
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant
Ephrin-B2/EFNB2	Human	EphrinB2/EFNB2 Protein, Recombinant
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2/Fc Protein, Recombinant
Ephrin-B2/EFNB2	Mouse	EphrinB2/EFNB2 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Ephrin-A1/EFNA1	WB, ELISA	Mouse Monoclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A1/EFNA1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse EphB4	WB, ELISA	EphB4 Antibody
Mouse EphB4	WB, ELISA	EphB4 Antibody (Antigen Affinity Purified)
Mouse EphB4	WB, ELISA	EphB4 Antibody
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody
Human Ephrin-A5/EFNA5	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
EphA3	Human	Homo sapiens EphA3 cDNA Clone
EphA4	Human	Homo sapiens EphA4 cDNA Clone
EphA4	Mouse	Mus musculus EphA4 cDNA Clone
EphA6/EHK-2	Mouse	Mus musculus EphA6/EHK2 cDNA Clone
EphA7	Human	Homo sapiens EphA7 cDNA Clone
EphA7	Mouse	Mus musculus EphA7 cDNA Clone
EphB2	Human	Homo sapiens EphB2 cDNA Clone
EphB4	Human	Homo sapiens EphB4 cDNA Clone(NM_004444.4)
EphB6	Human	Homo sapiens EphB6 cDNA Clone(NM_004445.2)
Ephrin-A1/EFNA1	Human	Homo sapiens Ephrin-A1/EFNA1 cDNA Clone(NM_004-428.2)
Ephrin-A1/EFNA1	Human	Homo sapiens Ephrin-A3/EFNA3 cDNA Clone(NM_004952.4)
Ephrin-A4/EFNA4	Human	Homo sapiens Ephrin-A4/EFNA4 cDNA Clone
Ephrin-A5/EFNA5	Human	Homo sapiens Ephrin-A5/EFNA5 cDNA Clone(NM_001962.1)
Ephrin-A5/EFNA5	Mouse	Mus musculus Ephrin-A5/EFNA5 cDNA Clone
Ephrin-B1/EFNB1	Human	Homo sapiens Ephrin-B1/EFNB1 cDNA Clone(NM_004429.4)
Ephrin-B1/EFNB1	Mouse	Mus musculus Ephrin-B1/EFNB1 cDNA Clone
Ephrin-B2/EFNB2	Human	Homo sapiens Ephrin-B2/EFNB2 cDNA Clone(NM_004093.2)
Ephrin-B2/EFNB2	Mouse	Mus musculus EphrinB2/EFNB2 cDNA Clone

EphB4 Background

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.

EphB4 Related Studies

1. Davalos V, et al. (2006) EPHB4 and survival of colorectal cancer patients. Cancer Res. 66(18): 8943-8.
2. Zhao C, et al. (2006) Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 4(2): 111-21.
3. Kertesz N, et al. (2006) The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood. 107(6): 2330-8.
4. Noren NK, et al. (2007) Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67(9): 3994-7.
5. Taylor AC, et al. (2007) EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker. Microcirculation. 14(3): 253-67.