EphB3 / HEK2 Protein & Antibody

Eph receptor B3

EphB3 / HEK2 Products

EphB3 / HEK2 Protein, Recombinant

Molecule	Species	Description	Cat. No
EphB3/HEK2	Mouse	EphB3/HEK2 Protein, Recombinant	50581-M08H

  50581-M08H: Immobilized mouse EphB3 at 2 µg/ml (100 µl/well) can bind mouse EFNB1 with a linear range of 0.1-12.5 ng/ml. Measured by its binding ability in a functional ELISA.

EphB3 / HEK2 Antibody

Molecule	Application	Description	Cat. No
Mouse EphB3/HEK2	WB, ELISA	EphB3 / HEK2 Antibody (Antigen Affinity Purified)	50581-RP02

EphB3 / HEK2 cDNA Clone

Molecule	Species	Description	Cat. No
EphB3/HEK2	Mouse	Mus musculus EphB3/HEK2 cDNA Clone	MG50581-M

EphB3 / HEK2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB3/HEK2

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB3/HEK2

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB3/HEK2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB3/HEK2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB3/HEK2

EphB3 / HEK2 Alternative Names

EphB3, HEK2, ETK2, TYRO6 [Homo sapiens]

Ephb3, HEK2, Etk2, Tyro6, AW456895, Cek10, MDK5, Sek4 [Mus musculus]

EphB3 / HEK2 Background

Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

EphB3 / HEK2 Related Studies

1. Bergemann AD, et al. (1998) Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 16(4): 471-80.
2. Hock B, et al. (1998) PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 95(17): 9779-84.
3. Liu X, et al. (2006) EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 26(12): 3087-101.