Anti-EphB3 Antibody

Cat: 50581-R115

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Anti-EphB3 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-EphB3 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse EphB3
No cross-reactivity in ELISA with Human LRPAP1
Recombinant Mouse EphB3 / HEK2 protein (Catalog#50581-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphB3 / HEK2 (rM EphB3 / HEK2; Catalog#50581-M08H; NP_034273.1; Met 1-Thr 537).
Monoclonal Rabbit IgG Clone #115
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphB3 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphB3 Antibody Alternative Names
Anti-AW456895 Antibody;Anti-Cek10 Antibody;Anti-Etk2 Antibody;Anti-HEK2 Antibody;Anti-MDK5 Antibody;Anti-Sek4 Antibody;Anti-Tyro6 Antibody
EphB3 Background Information

Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Full Name
EPH receptor B3
  • Bergemann AD, et al. (1998) Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 16(4): 471-80.
  • Hock B, et al. (1998) PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 95(17): 9779-84.
  • Liu X, et al. (2006) EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 26(12): 3087-101.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphB3 Antibody Rabbit Polyclonal WB,IP 81593-T36
    Anti-EphB3 Antibody (APC) Rabbit Monoclonal FCM 50581-R001-A
    Anti-EphB3 Antibody Rabbit Monoclonal FCM 50581-R001
    Anti-EphB3 Antibody (PE) Rabbit Monoclonal FCM 50581-R001-P
    Anti-EphB3 Antibody Rabbit Polyclonal ELISA 50581-RP02
    Anti-EphB3 Antibody Rabbit Polyclonal ELISA 13925-RP01
    Anti-EphB3 Antibody Rabbit Polyclonal ELISA,IHC-P 13925-RP02
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