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> EphB2 Protein & Antibody EphB2 Protein & Antibody
Eph receptor B2
EphB2 Products
EphB2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| EphB2 | Human | EphB2/Fc Protein, Recombinant  |
10762-H03H |
| EphB2 | Human | EphB2 Protein, Recombinant |
10762-H08H |
| EphB2 | Human | EPHB2 / Hek5 (aa 570-987) Protein, with GST Tag | 10762-H20B1 |
10762-H03H Measured by its ability to bind recombinant human EphrinB2 in a functional ELISA.
EphB2 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human EphB2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10762-RP01 |
| Human EphB2 |
WB, ELISA | EphB2 Antibody | 10762-RP02 |
| Human EphB2 |
WB, ELISA | EphB2 / EPHB2 Antibody | 10762-R125 |
EphB2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| EphB2 | Human | Homo sapiens EphB2 cDNA Clone | HG10762-M |
EphB2 Alternative Names
EphB2, ERK, Hek5, Tyro5, CAPB, DRT, EPHT3, MGC87492, PCBC [Homo sapiens]
Ephb2, Erk, Hek5, Tyro5, RP23-426N4.7, Cek5, Drt, ETECK, Nuk, Prkm5, Qek5, Sek3 [Mus musculus]
EphB2 Related Areas
Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB2
Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB2
Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB2
Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB2
Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB2
EphB2 Related Products
Protein Products
Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human EphB4 |
WB | Mouse Monoclonal Antibody |
| Human EphB4 |
ELISA | Mouse Monoclonal Antibody |
| Human EphB4 |
WB, ELISA | Rabbit Monoclonal Antibody |
| Human EphB4 |
ELISA | Rabbit Polyclonal Antibody |
| Human EphB4 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Mouse Monoclonal Antibody |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human Ephrin-A1/EFNA1 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human Ephrin-A5/EFNA5 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human Ephrin-A5/EFNA5 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
cDNA Clone Products
EphB2 Background
Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
EphB2 Related Studies
- Zisch AH, et al. (1998) Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16 (20): 2657-70.
- Yu HH, et al. (2001) Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20 (30): 3995-4006.
- Zisch AH, et al. (2000) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19 (2): 177-87.
