Anti-EphB2 Antibody

Cat: 10762-R125
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All EphB2 Reagents
Anti-EphB2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-EphB2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human EphB2
Recombinant Human EphB2 protein (Catalog#10762-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human EphB2 (rh EphB2; Catalog#10762-H08H; NP_059145.2; Met 1-Leu 543).
Monoclonal Rabbit IgG Clone #125
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphB2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphB2 Antibody Alternative Names
Anti-CAPB Antibody;Anti-DRT Antibody;Anti-EK5 Antibody;Anti-EPHT3 Antibody;Anti-ERK Antibody;Anti-Hek5 Antibody;Anti-PCBC Antibody;Anti-Tyro5 Antibody
EphB2 Background Information

Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Full Name
EPH receptor B2
  • Zisch AH, et al. (1998) Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16 (20): 2657-70.
  • Yu HH, et al. (2001) Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20 (30): 3995-4006.
  • Zisch AH, et al. (2000) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19 (2): 177-87.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphB2 Antibody Rabbit Polyclonal IHC-P 106732-T08
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    Anti-EphB2 Antibody (PE) Rabbit Monoclonal FCM 10762-R001-P
    Anti-EphB2 Antibody Rabbit Polyclonal ELISA 10762-RP02
    Anti-EphB2 Antibody Rabbit Polyclonal ELISA 10762-RP01
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