EphB1 Protein

EPH receptor B1

EphB1 Products

EphB1 Protein, Recombinant

Molecule	Species	Description	Cat. No
EphB1	Human	EphB1 Protein, Recombinant	11963-H08H
EphB1	Mouse	EphB1 Protein, Recombinant	50479-M08H
EphB1	Mouse	EphB1 Protein, Recombinant, with GST Tag	50479-M20B

EphB1 Antibody

Molecule	Application	Description	Cat. No
Human EphB1	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11963-RP02

EphB1 cDNA Clone

Molecule	Species	Description	Cat. No
EphB1	Mouse	Mus musculus EphB1 cDNA Clone	MG50479-M

EphB1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB1

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB1

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB1

EphB1 Alternative Names

EPHB1, ELK, EPHT2, FLJ37986, Hek6, NET [Homo sapiens]

Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net [Mus musculus]

EphB1 Background

Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

EphB1 Related Studies

1. Dalva MB, et al. (2000) EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell. 103(6): 945-56.
2. Takasu MA, et al. (2002) Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science. 295(5554): 491-5.
3. Adams RH, et al. (1999) Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13(3): 295-306.