Anti-EphA6 Antibody

Cat: 50630-R033
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Anti-EphA6 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-EphA6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse EphA6
Immunogen
Recombinant Mouse EphA6 protein (Catalog#50630-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphA6 / EHK2 (rM EphA6 / EHK2; Catalog#50630-M08H; NP_031964.2; Met 1-Gln 546).
Source
Monoclonal Rabbit IgG Clone #033
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphA6 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphA6 Antibody Alternative Names
Anti-Ehk2 Antibody;Anti-Hek12 Antibody;Anti-m-ehk2 Antibody
EphA6 Background Information

Ephrin type-A receptor 6, also known as EphA6 or EHK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. In the vomeronasal system, Ephrin-A5/EphA6 interactions mediate attraction or adhesion rather than repulsion.

Full Name
EPH receptor A6
References
  • Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196: 177-244.
  • Yamaguchi Y, et al. (2004) Eph receptors in the adult brain. Curr Opin Neurobiol. 14 (3): 288-96.
  • Hafner C, et al. (2004) Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Clin Chem. 50 (3): 490-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphA6 Antibody Rabbit Polyclonal ELISA,IHC-P 50630-T24
    Anti-EphA6 Antibody Rabbit Polyclonal ELISA 50630-RP02
    Anti-EphA6 Antibody Rabbit Polyclonal ELISA 50630-RP01
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