EphA6 / EHK2 Antibody

EphA6 Antibody Datasheet

EphA6 Antibody Product Information

• Immunogen: Recombinant Mouse EphA6 protein (Catalog#50630-M08H)
• Antibody Type: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
• Clone ID: 033
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphA6 / EHK2 (rM EphA6 / EHK2; Catalog#50630-M08H; NP_031964.2; Met 1-Gln 546).

EphA6 Antibody Usage Guide

• Specificity: Mouse EphA6
• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse EPHA6. The detection limit for Mouse EPHA6 is approximately 0.00975 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

EphA6 Antibody Background

Ephrin type-A receptor 6, also known as EPH homology kinase 2, Epha6, and Ehk-2, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and Ephrin receptor subfamily. It contains twofibronectin type-III domains, one protein kinase domain, and oneSAM (sterile alpha motif) domain. EphA6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits underlying aspects of learning and memory. EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4 and EPHB6 are EPH family receptors for Ephrin family ligands. Ephrin/EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Inmolecular biology,ephrinsandEph receptorsare components ofcell signalingpathways involved inanimaldevelopment, and implicated in some cancers. Eph receptors are classified asreceptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations.

References

1. Hafner, C. et al., 2004,Clin Chem. 50 (3): 490-9.
2. Katoh,M.et al., 2006, Int J Oncol. 28 (5): 1243-7.
3. Shaut, CA. et al., 2007, Dev Dyn. 236 (4): 951-60.
4. Savelieva, KV. et al., 2008, Neurosci Lett. 438 (2): 205-9.