All EphA4 reagents are produced in house and quality controlled, including 5 EphA4 Antibody, 52 EphA4 Gene, 9 EphA4 Lysate, 9 EphA4 Protein, 3 EphA4 qPCR. All EphA4 reagents are ready to use.
Recombinant EphA4 proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-human IgG1-Fc & His, C-His, N-GST & His, C-human IgG1-Fc.
EphA4antibodies are validated with different applications, which are ELISA, IHC-P.
EphA4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each EphA4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.