Anti-EphA4 Antibody

Cat: 11314-RP02
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Anti-EphA4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-EphA4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human EphA4
Immunogen
Recombinant Human EPHA4 protein (Catalog#11314-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human EPHA4 (rh EPHA4; Catalog#11314-H08H; NP_031962.2; Met 1-Thr 547). EPHA4 specific IgG was purified by human EPHA4 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphA4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphA4 Antibody Alternative Names
Anti-HEK8 Antibody;Anti-SEK Antibody;Anti-TYRO1 Antibody
EphA4 Background Information

EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.

Full Name
EPH receptor A4
References
  • Murai KK, et al. (2003) Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 6(2): 153-60.
  • Kullander K, et al. (2003) Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science. 299(5614): 1889-92.
  • Smith A, et al. (1997) The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr Biol. 7(8): 561-70.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphA4 Antibody Rabbit Polyclonal ELISA 90039-T16
    Anti-EphA4 Antibody Rabbit Polyclonal ELISA 50575-T16
    Anti-EphA4 Antibody Rabbit Polyclonal ELISA 11314-RP01
    Anti-EphA4 Antibody Rabbit Polyclonal ELISA,IHC-P 11314-T24
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