EphA2 Protein & Antibody

Eph receptor A2

EphA2 Products

EphA2 Protein, Recombinant

Molecule	Species	Description	Cat. No
EphA2	Mouse	EphA2 Protein, Recombinant	50586-M08H

  50586-M08H:

1. Immobilized mouse EphA2 at 2 µg/ml (100 µl/well) can bind mouse EphrinA1 with a linear range of 0.16-20 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized mouse EphA2 at 2 µg/ml (100 µl/well) can bind human EphrinA1 with a linear range of 0.8-20 ng/ml. Measured by its binding ability in a functional ELISA.

EphA2 Antibody

Molecule	Application	Description	Cat. No
Mouse EphA2	WB, ELISA	EphA2 Antibody	50586-RP01
Mouse EphA2	WB, ELISA	EphA2 Antibody (Antigen Affinity Purified)	50586-RP02

EphA2 cDNA Clone

Molecule	Species	Description	Cat. No
EphA2	Mouse	Mus musculus EphA2 cDNA Clone	MG50586-M

EphA2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphA2

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphA2

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphA2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphA2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphA2

EphA2 Alternative Names

EphA2, ARCC2, ECK [Homo sapiens]

Epha2, RP23-308N2.1, AW545284, Eck, Myk2, Sek-2, Sek2 [Mus musculus]

EphA2 Background

Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.

EphA2 Related Studies

1. Flanagan JG, et al. (1998) The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 21: 309-45.
2. Cheng N, et al. (2002) The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 13(1): 75-85.
3. Pratt RL, et al. (2002) Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene. 21(50): 7690-9.
4. Jennifer Walker-Daniels, et al. (2003) Differential Regulation of EphA2 in Normal and Malignant Cells. Am J Pathol. 162(4): 1037–1042.