Anti-EphA2 Antibody

Cat: 50586-RP02
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All EphA2 Reagents
CRO Services
Product recommended

All EphA2 Reagents
Anti-EphA2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-EphA2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse EphA2
Immunogen
Recombinant Mouse EphA2 protein (Catalog#50586-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse EphA2 (rM EphA2; Catalog#50586-M08H; NP_034269.2; Met 1-Asn 535). EphA2 specific IgG was purified by Mouse EphA2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EphA2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EphA2 Antibody Alternative Names
Anti-AW545284 Antibody;Anti-Eck Antibody;Anti-Myk2 Antibody;Anti-Sek-2 Antibody;Anti-Sek2 Antibody
EphA2 Background Information

Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.

Full Name
EPH receptor A2
References
  • Flanagan JG, et al. (1998) The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 21: 309-45.
  • Cheng N, et al. (2002) The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 13(1): 75-85.
  • Pratt RL, et al. (2002) Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene. 21(50): 7690-9.
  • Jennifer Walker-Daniels, et al. (2003) Differential Regulation of EphA2 in Normal and Malignant Cells. Am J Pathol. 162(4): 1037-1042.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EphA2 Antibody Rabbit Monoclonal ELISA,FCM 50586-R301
    Anti-EphA2 Antibody (FITC) Rabbit Monoclonal FCM 50586-R301-F
    Anti-EphA2 Antibody (APC) Rabbit Monoclonal FCM 50586-R101-A
    Anti-EphA2 Antibody Rabbit Polyclonal ELISA 50586-RP01
    Anti-EphA2 Antibody (PE) Rabbit Monoclonal FCM 50586-R101-P
    Anti-EphA2 Antibody Rabbit Monoclonal FCM 50586-R101
    Anti-EphA2 Antibody (FITC) Rabbit Monoclonal FCM 50586-R101-F
    Anti-EphA2 Antibody (PE) Rabbit Monoclonal FCM 50586-R301-P
    Anti-EphA2 Antibody Rabbit Polyclonal ELISA 13926-T16
    info info
    添加购物车成功! 添加购物车失败!