Mouse Epcr / PROCR Protein

Protein C receptor, endothelial Protein Datasheet

Epcr / PROCR Protein Product Information

• Synonym: RP23-388H13.2, AI325044, Ccca, Ccd41, Epcr
• Protein Construction: A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was fused with the Fc region of human IgG1 at the C-terminus.
• Source: Mouse
• Expression Host: Human Cells

Epcr / PROCR Protein QC Testing

• Purity: > 85 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Leu 18
• Molecular Mass: The secreted recombinant mouse PROCR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 438 amino acids and has a calculated molecular mass of 49.3 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 65-75 kDa in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS , pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: Epcr / PROCR protein

Epcr / PROCR Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Epcr / PROCR Protein Description

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells(cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occur when it does not. When still bound to EPCR, activated protein C performs its cytoprotective effects.

References

1. Nicolaes GA. et al., 2003, Semin Vasc Med. 3 (1): 33-46.
2. Esmon CT. 2003, Chest. 124 (3): 26-32.
3. Mosnier LO. et al., 2007, Blood. 109: 3161-3172.