Epcr / PROCR Protein

Protein C receptor, endothelial

PROCR Products

PROCR Protein, Recombinant

Molecule	Species	Description	Cat. No
PROCR	Human	Epcr / PROCR Protein, Recombinant	13320-H08H
PROCR	Mouse	Epcr / PROCR Protein, Recombinant	50874-M02H
PROCR	Mouse	EPCR / PROCR Protein, Recombinant	50874-M08H

PROCR cDNA Clone

Molecule	Species	Description	Cat. No
PROCR	Human	PROCR cDNA Clone / ORF Clone	HG13320-G
PROCR	Mouse	PROCR cDNA Clone / ORF Clone	MG50874-G
PROCR	Rat	PROCR cDNA Clone / ORF Clone	RG80362-G

PROCR Related Areas

Immunology>>Innate Immunity>>Coagulation>>PROCR

Cardiovascular>>Coagulation>>PROCR

PROCR Alternative Names

CCCA,CCD41,CD201,EPCR,MGC23024,bA42O4.2 [Homo sapiens]

RP23-388H13.2,AI325044,Ccca,Ccd41,Epcr [Mus musculus]

PROCR Background

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 

PROCR Related Studies

1. Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
2. Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
3. Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.