**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-EPCR Antibody (PE)||Rabbit||Monoclonal||FCM||50874-R016-P|
|Anti-EPCR Antibody (APC)||Rabbit||Monoclonal||FCM||50874-R016-A|
|Anti-EPCR Antibody (FITC)||Rabbit||Monoclonal||FCM||50874-R011-F|
|Anti-EPCR Antibody (FITC)||Rabbit||Monoclonal||FCM||50874-R016-F|