EpCAM cDNA ORF Clone in Cloning Vector, Human

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EpCAM cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
945 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human tumor-associated calcium signal transducer 1.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

EpCAM cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

EpCAM cDNA ORF Clone in Cloning Vector, Human: Alternative Names

DIAR5 cDNA ORF Clone, Human; EGP-2 cDNA ORF Clone, Human; EGP314 cDNA ORF Clone, Human; EGP40 cDNA ORF Clone, Human; ESA cDNA ORF Clone, Human; HNPCC8 cDNA ORF Clone, Human; KS1/4 cDNA ORF Clone, Human; KSA cDNA ORF Clone, Human; M4S1 cDNA ORF Clone, Human; MIC18 cDNA ORF Clone, Human; MK-1 cDNA ORF Clone, Human; TACSTD1 cDNA ORF Clone, Human; TROP-1 cDNA ORF Clone, Human; TROP1 cDNA ORF Clone, Human

EpCAM Background Information

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Full Name
epithelial cell adhesion molecule
References
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.

EpCAM cDNA ORF Clone, Mouse, Related Products

  • Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions
    Author
    Wieduwild, R;Howarth, M;
    Year
    2018
    Journal
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    Application
    template
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