Anti-EpCAM Antibody (FITC)

Cat: 10694-MM06-F
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Anti-EpCAM Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-EpCAM Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human EpCAM
Immunogen
Recombinant Human EpCAM / TROP1 / CD326 protein (Catalog#10694-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP1 / CD326 (rh EpCAM / TROP1 / CD326; Catalog#10694-H08H; NP_002345.1; Met 1-Lys 265) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #06
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-EpCAM Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EpCAM Antibody (FITC) (Mouse Monoclonal antibody) Images
Human EpCAM/TROP-1/TACSTD1 Flow Cytometry (FC) 2598
Profile of anti-EpCAM (CD326) reactivity on SKBR3 cells analyzed by flow cytometry.
Anti-EpCAM Antibody (FITC) Alternative Names
Anti-DIAR5 Antibody;Anti-EGP-2 Antibody;Anti-EGP314 Antibody;Anti-EGP40 Antibody;Anti-ESA Antibody;Anti-HNPCC8 Antibody;Anti-KS1/4 Antibody;Anti-KSA Antibody;Anti-M4S1 Antibody;Anti-MIC18 Antibody;Anti-MK-1 Antibody;Anti-TACSTD1 Antibody;Anti-TROP-1 Antibody;Anti-TROP1 Antibody
EpCAM Background Information

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
epithelial cell adhesion molecule
References
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
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