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EpCAM/TROP-1/TACSTD1 FITC Mouse MAb

  • EpCAM / TROP-1 / TACSTD1 Antibody (FITC), Mouse MAb, Flow cytometric
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Human EpCAM Antibody Product Information
Immunogen:Recombinant Human EpCAM / TROP1 / CD326 protein (Catalog#10694-H08H)
Clone ID:06
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP1 / CD326 (rh EpCAM / TROP1 / CD326; Catalog#10694-H08H; NP_002345.1; Met 1-Lys 265) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human EpCAM Antibody FC Application Image
EpCAM / TROP-1 / TACSTD1 Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Profile of anti-EpCAM (CD326) reactivity on SKBR3 cells analyzed by flow cytometry.
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          EpCAM/TROP-1/TACSTD1 Background

          Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

          Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human EpCAM/TROP-1/TACSTD1 References
        • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
        • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
        • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
        • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
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          Catalog: 10694-MM06-F-100
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"