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EpCAM/TROP-1/TACSTD1 PE Rabbit MAb

  • EpCAM / TROP-1 / TACSTD1 Antibody (PE), Rabbit MAb, Flow cytometric
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Mouse EPCAM Antibody Product Information
Immunogen:Recombinant Mouse EpCAM / TROP-1 / TACSTD1 protein (Catalog#50591-M08H)
Clone ID:023
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EpCAM / TROP-1 / TACSTD1 (rM EpCAM / TROP-1 / TACSTD1; Catalog#50591-M08H; NP_032558.2; Met1-Thr266) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Mouse EPCAM Antibody FC Application Image
EpCAM / TROP-1 / TACSTD1 Antibody (PE), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Analysis of EpCAM (CD326) expression on spleen lymphocytes.
Other EPCAM Antibody Products
EpCAM/TROP-1/TACSTD1 Background

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Mouse EpCAM/TROP-1/TACSTD1 References
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
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