Anti-EpCAM Antibody (PE)

Cat: 50591-R023-P
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Anti-EpCAM Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-EpCAM Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse EpCAM
Immunogen
Recombinant Mouse EpCAM / TROP-1 / TACSTD1 protein (Catalog#50591-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EpCAM / TROP-1 / TACSTD1 (rM EpCAM / TROP-1 / TACSTD1; Catalog#50591-M08H; NP_032558.2; Met1-Thr266) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #023
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-EpCAM Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EpCAM Antibody (PE) (Rabbit Monoclonal antibody) Images
Mouse EpCAM/TROP-1/TACSTD1 Flow Cytometry (FC) 5548
Analysis of EpCAM (CD326) expression on spleen lymphocytes.
Anti-EpCAM Antibody (PE) Alternative Names
Anti-CD326 Antibody;Anti-EGP Antibody;Anti-EGP-2 Antibody;Anti-Egp314 Antibody;Anti-Ep-CAM Antibody;Anti-EpCAM1 Antibody;Anti-GA733-2 Antibody;Anti-gp40 Antibody;Anti-Ly74 Antibody;Anti-Tacsd1 Antibody;Anti-Tacstd1 Antibody;Anti-TROP1 Antibody
EpCAM Background Information

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
epithelial cell adhesion molecule
References
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-EpCAM Antibody Rabbit Monoclonal ELISA(Cap) 50591-R052
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    Anti-EpCAM Antibody Rabbit Monoclonal IHC-P 50591-R065
    Anti-EpCAM Antibody (PE) Rabbit Monoclonal FCM 10694-R028-P
    Anti-EpCAM Antibody Rabbit Polyclonal WB,ELISA 10694-RP02
    Anti-EpCAM Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),IHC-P,FCM,ICC/IF,IF,IP 10694-R028
    Anti-EpCAM Antibody Rabbit Polyclonal WB,ELISA,IP 10694-T52
    Anti-EpCAM Antibody (APC) Mouse Monoclonal FCM 10694-MM06-A
    Anti-EpCAM Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10694-MM07
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA 10694-RP01
    Anti-EpCAM Antibody (FITC) Mouse Monoclonal FCM 10694-MM06-F
    Anti-EpCAM Antibody Mouse Monoclonal FCM 10694-MM06
    Anti-EpCAM Antibody (FITC) Rabbit Monoclonal FCM 10694-R028-F
    Anti-EpCAM Antibody (PE) Mouse Monoclonal FCM 10694-MM06-P
    Anti-EpCAM Antibody (APC) Rabbit Monoclonal FCM 10694-R028-A
    Anti-EpCAM Antibody Mouse Monoclonal WB,IP 10694-MM05
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