EpCAM / TROP-1 Protein & Antibody (TACSTD1)

Epithelial Cell Adhesion Molecule (Tumor-Associated Calcium Signal Transducer 1)

EpCAM / TROP-1 Products

EpCAM / TROP-1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
EpCAM/TROP-1/TACSTD1	Human	EpCAM/TROP-1/TACSTD1/Fc Protein, Recombinant	10694-H02H
EpCAM/TROP-1/TACSTD1	Human	EpCAM/TROP-1/TACSTD1 Protein, Recombinant	10694-H08H
EpCAM/TROP-1/TACSTD1	Mouse	EpCAM/TROP-1/TACSTD1 Protein, Recombinant	50591-M08H
EpCAM/TROP-1/TACSTD1	Rat	EPCAM Protein, Recombinant	80306-R02H
EpCAM/TROP-1/TACSTD1	Rat	EPCAM Protein, Recombinant	80306-R08H

  10694-H08H:  The EC50 of biotinylated EpCAM is 86.7 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized recombinant human Cathepsin V at 10 µg/mL (100 µl/well) can bind biotinylated EpCAM.

EpCAM / TROP-1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human EpCAM/TROP-1/TACSTD1	WB	Mouse Monoclonal Antibody	10694-MM05
Human EpCAM/TROP-1/TACSTD1	FCM	EpCAM / TROP1 / CD326 Antibody ( PE )	10694-MM06-P
Human EpCAM/TROP-1/TACSTD1	ELISA	Mouse Monoclonal Antibody	10694-MM07
Human EpCAM/TROP-1/TACSTD1	WB, ELISA, IHC-P	Rabbit Monoclonal Antibody	10694-R028
Human EpCAM/TROP-1/TACSTD1	WB, ELISA	Rabbit Polyclonal Antibody	10694-RP01
Human EpCAM/TROP-1/TACSTD1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10694-RP02
Mouse EpCAM/TROP-1/TACSTD1	WB, ELISA	EpCAM / TROP-1 / TACSTD1 Antibody	50591-RP01
Mouse EpCAM/TROP-1/TACSTD1	WB, ELISA	EpCAM / TROP-1 / TACSTD1 Antibody (Antigen Affinity Purified)	50591-RP02
Mouse EpCAM/TROP-1/TACSTD1	WB, ELISA	EpCAM / TROP-1 / TACSTD1 Antibody (Antigen Affinity Purified)	50591-RP02
Mouse EpCAM/TROP-1/TACSTD1	WB, ELISA	EpCAM / TROP-1 / TACSTD1 Antibody	50591-R002

EpCAM / TROP-1 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human EpCAM/TROP-1/TACSTD1	ELISA	EpCAM/TROP-1/TACSTD1 ELISA Kit	SEK10694

EpCAM / TROP-1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
EpCAM/TROP-1/TACSTD1	Human	EpCAM/TROP1 cDNA Clone / ORF Clone	HG10694-M
EpCAM/TROP-1/TACSTD1	Rat	EPCAM cDNA Clone / ORF Clone	RG80306-G

EpCAM / TROP-1 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>EpCAM/TROP-1/TACSTD1

Cancer>>Cancer Biomarkers>>EpCAM/TROP-1/TACSTD1

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>EpCAM/TROP-1/TACSTD1

Immunology>>Cluster of Differentiation>>Other>>EpCAM/TROP-1/TACSTD1/CD326

EpCAM / TROP-1 Alternative Names

EPCAM, TROP1, TACSTD1, Ep-CAM, TACST-1, EGP, EGP-2, CO-17A, CO17-1A, EGP34, EGP40, ESA, GA733-2, KS1/4, KSA, M4S1, MIC18, MK-1, hEGP-2 [Homo sapiens]

Epcam, TROP1, Tacstd1, Ep-CAM, CD326, Tacsd1, EGP, EGP-2, Egp314, GA733-2, Ly74, gp40 [Mus musculus]

EpCAM / TROP-1 Background

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

EpCAM / TROP-1 Related Studies

1. Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
2. Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
3. Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
4. Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.