All EpCAM reagents are produced in house and quality controlled, including 21 EpCAM Antibody, 2 EpCAM ELISA, 36 EpCAM Gene, 4 EpCAM IPKit, 10 EpCAM Lysate, 10 EpCAM Protein, 2 EpCAM qPCR. All EpCAM reagents are ready to use.
Recombinant EpCAM proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-human IgG1-Fc, C-His, C-cleavage.
EpCAMantibodies are validated with different applications, which are FCM, IHC-P, WB, ELISA, IP, ELISA(Det), ICC/IF, IF, ELISA(Cap).
EpCAMcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each EpCAM of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
EpCAMELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: HEK293 Cells
Expression host: Baculovirus-Insect Cells
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.